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Plays a role in the regulation of cell morphology and cytoskeletal organization.. Additionally we are shipping LARP4 Proteins (2) and and many more products for this protein.
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The results indicate that LARP4 is a posttranscriptional regulator of ribosomal protein production in mammalian cells and suggest that this activity can be controlled by tRNA levels.
A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA.
LARP4 inhibits migration and invasion of cancer cells, and that some cancer-associated mutations stimulate these effects of LARP4.
Involvement of LARP4 as a target of T (show TNF Antibodies)NF-alpha- (show ADAMTS13 Antibodies)TTP regulation provides a clue as to how its functional activity may be used in a physiologic pathway.
The results demonstrate that the La modules of the human LARP4 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
LARP4 activity is integrated with other PAM2 protein activities by PABP as part of mRNA homeostasis.
The c-MPL (show MPL Antibodies) protein altered expression provide an opportunity to diagnose and identify subpopulations of MPD (show MVD Antibodies) patients.
Mouse LARP4 is regulated by TNF-alpha (show TNF Antibodies) in a TTP (show ZFP36 Antibodies)-dependent manner.
Plays a role in the regulation of cell morphology and cytoskeletal organization.
La ribonucleoprotein domain family, member 4
, c-Mpl binding protein
, la-related protein 4