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Mouse studies suggest that LPIN2 functions during normal adipose tissue development and may play a role in human triglyceride metabolism. Additionally we are shipping Lipin 2 Proteins (3) and many more products for this protein.
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Human Polyclonal LPIN2 Primary Antibody for ELISA - ABIN4229823
Phan, Péterfy, Reue: Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. in The Journal of biological chemistry 2004
lipin-2 control TLR4 (show TLR4 Antibodies) signaling, and P2X7R (show P2RX7 Antibodies) activation and sensitization, that finally culminate in a restricted activation of NLRP3 (show NLRP3 Antibodies) inflammasome.
we proposed that four newly identified peripheral blood mononuclear cells-derived genes( DHRS3 (show DHRS3 Antibodies), TTC38, SAP30BP (show SAP30BP Antibodies) and LPIN2 )could be integrated with previously reported rheumatoid arthritis (RA)-associated genes to monitor and/or diagnose RA.
Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a (show PPARGC1A Antibodies) that is important for lipid metabolism and for suppressing autoinflammation.
We describe two brothers with Majeed syndrome, homozygous novel 2 (show TSPAN4 Antibodies)-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X)
LPIN1 (show LPIN1 Antibodies)-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 (show LPIN1 Antibodies) mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 (show LPIN3 Antibodies) genes were associated with muscle manifestations.
role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages
Data revealed that lipin 1 (show LPIN1 Antibodies) formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3.
LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene.
We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology
A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution.
distinct and non-redundant functions of lipin 1 (show LPIN1 Antibodies) and 2 regulate lipid production during the cell cycle and adipocyte differentiation
Association analysis showed that different genotypes of LPIN2 were associated with back-fat thickness between the 6th and 7th ribs (P < 0.01).
Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond but the phosphorylation of lipin 2 is not induced by insulin (show INS Antibodies) signaling.
in addition to their roles during early adipogenesis, lipin1 (show LPIN1 Antibodies) and lipin2 also have a role in lipid droplet biogenesis.
Mouse lipin-1 (show LPIN1 Antibodies) and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Data show that in the high-Chol diet apoE (show APOE Antibodies)-KO mice, the mRNA and protein expression of lipin-1 (show LPIN1 Antibodies) and lipin-2 was markedly decreased.
The results demonstrate that ER stress-induced LIPIN2 would contribute to the perturbation of hepatic insulin (show INS Antibodies) signaling via a DAG-protein kinase C epsilon (show PRKCE Antibodies)-dependent manner in DIO mice.
Lipin-2 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
lipin 2 plays an important role as a hepatic PAP-1 enzyme.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 (show LPIN1 Antibodies) and lipin-2.
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
, phosphatidate phosphatase LPIN2
, phosphatidate phosphatase LPIN2-like