anti-Lysyl Oxidase (LOX) Antibodies

The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Additionally we are shipping LOX Kits (54) and LOX Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LOX 4015 P28300
LOX 16948 P28301
LOX 24914 P16636
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Top anti-LOX Antibodies at antibodies-online.com

Showing 10 out of 190 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Simple Western: LOX Antibody [ABIN4331341] - Simple Western lane view shows a specific band detected for LOX in HeLa lysate. This experiment was performed under reducing conditions using the Wes or Sally Sue separation system 12-230kDa (or 66-440kDa). Simple Western: LOX Antibody [ABIN4331341] - Simple Western lane view shows a specific band for LOX in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230kDa separation system. 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Cow Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Immunohistochemistry: LOX Antibody [ABIN250966] - Human placental villi, 40X. Staining of placental trophoblasts using ABIN250966 at 10 ug/ml. Detection of LOX in mouse kidney lysate using ABIN250966 (1:1,000). ECL detection was 15 sec. 0.05 mL Log in to see 7 to 9 Days
$446.35
Details
Cow Rabbit Un-conjugated ICC, IF, IHC (fro), IHC (p), IP, WB Western Blot: LOX Antibody [NBP2-24877] - Western blot analysis of mouse ear lysate when LOX antibody (NBP2-24877) was used at 1:1000. The band shown is the expected inactive 50 kD proenzyme. Immunohistochemistry-Paraffin: LOX Antibody [NBP2-24877] - Analysis of LOX in formalin-fixed, paraffin-embedded mouse skin using an isotype control (top) and NBP2-24877 (bottom) at 1:100. 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB Staining of LOX in mouse spleen using ABIN258622. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Staining of LOPP in mouse intestine using ABIN258371. Western Blot: LOX propeptide Antibody [ABIN2583718] - Detection of LOPP in MC3T3-E1 cell lysate. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated FACS, ICC, IF, IP, SimWes, WB Flow Cytometry: LOX propeptide Antibody [NBP1-30327] - Staining of NTERA-2 cells using NP1-30327 at a 1:200 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary antibody. Immunocytochemistry/Immunofluorescence: LOX propeptide Antibody [NBP1-30327] - Staining in Hela cells detected with a Dylight 488 labeled secondary antibody (Green) with Hoechst 33258 nuclear counterstain (Blue). 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details

Top referenced anti-LOX Antibodies

  1. Human Polyclonal LOX Primary Antibody for ICC, IF - ABIN4331341 : Ovchinnikova, Robertson, Wågsäter, Folco, Hyry, Myllyharju, Eriksson, Libby, Hansson: T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. in The American journal of pathology 2009 (PubMed)
    Show all 17 Pubmed References

  2. Cow (Bovine) Polyclonal LOX Primary Antibody for ICC, IF - ABIN4331351 : Atsawasuwan, Mochida, Katafuchi, Kaku, Fong, Csiszar, Yamauchi: Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity. in The Journal of biological chemistry 2008 (PubMed)
    Show all 14 Pubmed References

  3. Cow (Bovine) Polyclonal LOX Primary Antibody for ICC, IF - ABIN250966 : Wilhelmus, Bol, van Duinen, Drukarch: Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type. in Experimental gerontology 2013 (PubMed)
    Show all 12 Pubmed References

  4. Human Polyclonal LOX Primary Antibody for ICC, IHC (fro) - ABIN258622 : Jeay, Pianetti, Kagan, Sonenshein: Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. in Molecular and cellular biology 2003 (PubMed)
    Show all 9 Pubmed References

  5. Human Polyclonal LOX Primary Antibody for ICC, IF - ABIN258371 : Palamakumbura, Jeay, Guo, Pischon, Sommer, Sonenshein, Trackman: The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal LOX Primary Antibody for FACS, ICC - ABIN447477 : Sato, Trackman, Mäki, Myllyharju, Kirsch, Sonenshein: The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. in Molecular and cellular biology 2011 (PubMed)
    Show all 4 Pubmed References

  7. Polyclonal LOX Primary Antibody for IHC (fro), WB - ABIN540694 : Trackman, Bedell-Hogan, Tang, Kagan: Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor. in The Journal of biological chemistry 1992 (PubMed)
    Show all 5 Pubmed References

  8. Polyclonal LOX Primary Antibody for IHC (p), WB - ABIN540432 : Guo, Pischon, Palamakumbura, Trackman: Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells. in American journal of physiology. Cell physiology 2007 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal LOX Primary Antibody for WB - ABIN1882262 : Gao, Xiao, Ma, Li, Liu, Feng, Fang, Wu, Han, Zhang, Sun, Wu, Padera, Chen, Wong, Ge, Ji: LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal LOX Primary Antibody for WB - ABIN1882261 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 3 Pubmed References

More Antibodies against LOX Interaction Partners

Zebrafish Lysyl Oxidase (LOX) interaction partners

  1. Partial knockdown of lysyl oxidase genes sensitizes the developing embryo to dithiocarbamate exposure.

  2. Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.

Human Lysyl Oxidase (LOX) interaction partners

  1. LOX regulates EGFR cell surface retention to drive tumour progression.

  2. The Epithelial-mesenchymal transition (EMT) marker Lox has a differential expression pattern in breast cancer, being significantly overexpressed in triple negative breast cancers.

  3. Studies indicate that the mature enzyme plays a key role in modifying the extracellular matrix and as a result has been implicated in playing a role in the formation of cancer "niches" where tumors will develop and eventually metastasize [Review].

  4. Our results indicate the involvement of LOX in the initiation of fibrous capsule formation which ultimately contributes towards the progression of capsular contracture

  5. this study has revealed that IL-1beta may contribute to the rupture of fetal membranes by attenuating collagen crosslinking through downregulation of LOX expression in amnion fibroblasts

  6. This study focused on the relationship between lysyl oxidase (LOX), LOX-like protein 1 (LOXL1), and LOXL2 and pulmonary emphysema pathogenesis.

  7. The aim was to examine if the serum concentrations of elastin-related proteins correlate to signs of cardiovascular diseases in patients with Diabetes mellitus type 2.

  8. LOX role in cancer stromal cells activation and promotion of gastric cancer progression

  9. an association of LOX gene polymorphism (G473A) on diabetes and DFU patients

  10. LOX expression was mildly but significantly upregulated in CD34+-derived primary myelofibrosis megakaryocytes and platelets compared with controls. These megakaryocytes showed a greater tendency to adhere and spread to monomeric collagen, and this was inhibited by the LOX-specific inhibitor BAPN.

  11. Data suggest that a missense mutation in lysyl oxidase (LOX) is associated with aortic disease.

  12. Our findings suggest that LOX has a role in cancer cell mitosis

  13. Our findings provide new evidence that LOX regulates SNAI2 expression and that SNAI2-mediated TIMP4 secretion plays a role in cancer progression.

  14. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.

  15. LOX is a prognostic factor for poor progression free survival in patients with ER- breast cancer. LOX overexpression was positively correlated with resistance to radiation and drug therapy.

  16. This preliminary study indicated that LOX gene polymorphisms, such as rs2303656, rs3900446, and rs763497, may play crucial roles in intracranial aneurysm formation in the Korean population.

  17. Results show that CTGF mediates the GDF8-induced up-regulation of LOX expression and increases in LOX activity in human granulosa cells.

  18. The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF in the South Indian population correlating with lowered LOX activity in the aqueous humor. The increased level of total TGF-beta in the aqueous humor of PXF cases is possibly associated with LOX regulation which needs further investigation.

  19. These findings suggest that LOX induces an age-dependent disturbance of diastolic function and aggravates Ang II-induced hypertrophy, which provides novel insights into the role of LOX in cardiac performance.

  20. LOX, a hypoxia-responsive gene that encodes lysyl oxidase, is activated by HIF-2-alpha more than HIF-1. Two new hypoxia response elements identified in the LOX promoter mediate most HIF responsiveness.

Pig (Porcine) Lysyl Oxidase (LOX) interaction partners

  1. Statins normalize vascular lysyl oxidase (LOX) down-regulation induced by proatherogenic risk factors.

Cow (Bovine) Lysyl Oxidase (LOX) interaction partners

  1. These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.

  2. Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells

  3. Lysyl oxidase has a role in oxidizing basic fibroblast growth factor and inactivating its mitogenic potential

  4. In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.

  5. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.

Mouse (Murine) Lysyl Oxidase (LOX) interaction partners

  1. LOX over-expression in vascular smooth muscle cells was associated with a change in the structure of collagen and elastin fibres; LOX could constitute a novel source of oxidative stress that might participate in elastin changes and contribute to vascular remodelling

  2. LOX up-regulation is associated with enhanced oxidative stress that promotes p38MAPK activation, elastin structural alterations, and vascular stiffness.

  3. These results suggest that LOX has the ability to induce RANKL expression on stromal cells; however, it fails to substitute for RANKL in osteoclastogenesis.

  4. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.

  5. Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling.

  6. LOX targeting reduces peritoneal fibrosis.

  7. Absence of lysyl oxidase (Lox) causes thoracic aortic aneurysms. The aortic mechanical behavior of Lox(-/-) mice is consistent with reduced elastin and collagen cross-linking but demonstrates vascular location-specific differences. Lox(-/-) aortas show upregulation of matrix remodeling genes and location-specific differential expression of other matrix and smooth muscle cell gene sets.

  8. Findings from this study indicate that preventing LOX overexpression may be protective against high glucose-induced apoptosis in retinal vascular cells associated with diabetic retinopathy.

  9. LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery

  10. Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.

  11. The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

  12. Data suggest of pharmacologic targeting of lysyl oxidase (LOX) pathway to inhibit liver fibrosis and promote its resolution.

  13. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A is required for VEGF-induced angiogenesis via activation of Cu enzyme lysyl oxidase.

  14. CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

  15. Inhibition of tissue transglutaminase resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction.

  16. decreased expression of cross-linking enzymes (LOXs) and increased expression of ECM-degrading proteinases (MMP-1, 2, 3) might be of great contribution to poor healing ability of PCL ligament

  17. LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury.

  18. LOX and LOXL2 may play an important role in the pathogenesis of AMD. Targeting LOXL2 could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis.

  19. LOX plays a critical role in vascular remodelling

  20. LOX is a novel regulator of NFATc1-driven osteoclastogenesis, independent of RANK ligand, which disrupts normal bone homeostasis leading to the formation of focal pre-metastatic lesions

LOX Antigen Profile

Protein Summary

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Lysyl Oxidase (LOX) Antibodies

  • lysyl oxidase (LOX) antibody
  • lysyl oxidase (lox) antibody
  • lysyl oxidase a (loxa) antibody
  • lysyl oxidase L homeolog (lox.L) antibody
  • lysyl oxidase (Lox) antibody
  • AI893619 antibody
  • H-rev142 antibody
  • lox antibody
  • MGC146507 antibody
  • Rrg1 antibody
  • TSC-160 antibody
  • Xlox antibody
  • zgc:77447 antibody

Protein level used designations for anti-Lysyl Oxidase (LOX) Antibodies

lysyl oxidase , protein-lysine 6-oxidase-like , protein-lysine 6-oxidase , ras excision protein , ras recision gene (rrg) , Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)

GENE ID SPECIES
471614 Pan troglodytes
699997 Macaca mulatta
780067 Xenopus (Silurana) tropicalis
100189621 Oncorhynchus mykiss
100457685 Pongo abelii
404621 Danio rerio
734204 Xenopus laevis
4015 Homo sapiens
100525278 Sus scrofa
280841 Bos taurus
16948 Mus musculus
24914 Rattus norvegicus
396474 Gallus gallus
481478 Canis lupus familiaris
100720740 Cavia porcellus
100357045 Oryctolagus cuniculus
101112220 Ovis aries
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