anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Proteins (8) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-EVI1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB <b>WB Suggested Anti-MDS1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Raji cell lysate WB Suggested Anti-MDS1 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <br /> Positive Control: Raji cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Mouse Un-conjugated WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details

MECOM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)


Top referenced anti-MDS1 and EVI1 Complex Locus Antibodies

  1. Human Polyclonal MECOM Primary Antibody for ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. in Journal of leukocyte biology 2009 (PubMed)

More Antibodies against MDS1 and EVI1 Complex Locus Interaction Partners

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (show ETS1 Antibodies)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  2. The expression of EVI1 and SOX9 (show SOX9 Antibodies) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 Antibodies) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 Antibodies) targeting failure

  3. EVI1 contributes to PCa (show FLVCR1 Antibodies) progression by regulating different oncogenic functions. EVI1 regulates the PCa (show FLVCR1 Antibodies) stem cell compartment responsible for disease initiation and also development of CRPC.

  4. oncogenic potential for EVI1 in modulating genomic stability

  5. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  6. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (show CKMT1B Antibodies) expression by repressing the myeloid differentiation regulator RUNX1 (show RUNX1 Antibodies).

  7. EVI1 transcription is directly regulated by LEF1 (show LEF1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) complex in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Antibodies). Loss of p53 (show TP53 Antibodies) function as a key regulator for beta-catenin (show CTNNB1 Antibodies)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Antibodies).

  8. we demonstrated that miR (show MLXIP Antibodies)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (show MLXIP Antibodies)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (show MLXIP Antibodies)-22-mediated MECOM degradation increased c-Jun (show JUN Antibodies) but decreased GATA2 (show GATA2 Antibodies) expression, which results in increased interaction between c-Jun (show JUN Antibodies) and PU.1

  9. Results establish the oncogenic contributions of EVI1 in ER- and HER2 (show ERBB2 Antibodies)-negative subsets of breast cancer.

  10. MECOM gene harbors both somatic frameshift mutations.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (show GATA2 Antibodies) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Antibodies) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Antibodies), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Antibodies) levels.

  5. Survivin (show BIRC5 Antibodies) partially regulates HSC (show FUT1 Antibodies) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (show PRDM16 Antibodies) and Prdm3 control postnatal BAT (show BAAT Antibodies) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Antibodies)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Antibodies), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Antibodies) with short latencies in a mouse bone marow transplantation model.

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Antibodies) signaling

  2. Prdm3 and prdm16 (show PRDM16 Antibodies) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 (show RUNX1 Antibodies) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Protein Summary

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus L homeolog (mecom.L) antibody
  • AML1-EVI-1 antibody
  • D630039M04Rik antibody
  • evi-1 antibody
  • evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • mecom antibody
  • mecom-a antibody
  • mecom-b antibody
  • prdm3 antibody
  • xEvi-1 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
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