anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Proteins (9) and MDS1 and EVI1 Complex Locus Kits (4) and many more products for this protein.

Gene Name	GeneID	UniProt
MECOM	2122	Q03112 , Q13465
MECOM	14013	Q9Z1L8
MECOM	294924

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Top anti-MDS1 and EVI1 Complex Locus Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2777403	Cow	Rabbit	Un-conjugated	IHC, WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN2787657	Cow	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN2787743	Human	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN2780631	Human	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$229.00	Details
ABIN2464631	Human	Goat	Un-conjugated	ELISA, WB	0.1 mg	Log in to see	2 to 3 Days	$481.25	Details
ABIN4270672	Human	Goat	Un-conjugated	ELISA, WB	0.1 mg	Log in to see	7 to 9 Days	$485.88	Details
ABIN952135	Human	Rabbit	Un-conjugated	EIA, WB	0.4 mL	Log in to see	6 to 8 Days	$390.50	Details
ABIN953364	Human	Rabbit	Un-conjugated	EIA, WB	0.4 mL	Log in to see	6 to 8 Days	$390.50	Details
ABIN202037	Human	Rabbit	Un-conjugated	WB	100 μg	Log in to see	7 to 9 Days	$493.17	Details
ABIN490659	Dog	Goat	Un-conjugated	ELISA, WB	100 μg	Log in to see	7 to 9 Days	$610.50	Details

MECOM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes	Applications	Host	Clonality	Conjugate
Human	, , , ,	, ,	,	, , , , ,
Mouse (Murine)		,	,	, , , , ,
Rat (Rattus)

More product categories related to MDS1 and EVI1 Complex Locus Antibody

Top referenced anti-MDS1 and EVI1 Complex Locus Antibodies

Human Polyclonal MECOM Primary Antibody for ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. in Journal of leukocyte biology 2009 (PubMed)

More Antibodies against MDS1 and EVI1 Complex Locus Interaction Partners

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

High EVI1 expression predicts poor outcome in Acute myeloid leukemia (show BCL11A Antibodies) with intermediate cytogenetic risk in patients receiving chemotherapy.
The relationship between EVI1 and microRNAs in human malignancies. [review]
Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B (show INPP4B Antibodies) in AML (show RUNX1 Antibodies); a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan (show SUPT6H Antibodies)-cancer analysis of INPP4B's prognostic significance
Letter/Case Report: ETV6 (show ETV6 Antibodies)/MECOM gene fusion in therapy-related acute myeloid leukemia (show BCL11A Antibodies) with t(3;12) and monosomy 7.
These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs
Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (show ETS1 Antibodies)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis
The expression of EVI1 and SOX9 (show SOX9 Antibodies) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 Antibodies) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 Antibodies) targeting failure
EVI1 contributes to PCa (show FLVCR1 Antibodies) progression by regulating different oncogenic functions. EVI1 regulates the PCa (show FLVCR1 Antibodies) stem cell compartment responsible for disease initiation and also development of CRPC.
oncogenic potential for EVI1 in modulating genomic stability
EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs
Gata2 (show GATA2 Antibodies) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice
EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.
the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Antibodies) from EVI1-induced suppression.
Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Antibodies), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Antibodies) levels.
Survivin (show BIRC5 Antibodies) partially regulates HSC (show FUT1 Antibodies) function by modulating the Evi-1 transcription factor and its downstream targets
Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Prdm16 (show PRDM16 Antibodies) and Prdm3 control postnatal BAT (show BAAT Antibodies) identity and function.
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Antibodies)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Antibodies) signaling
Prdm3 and prdm16 (show PRDM16 Antibodies) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

Evi-1 (show RUNX1 Antibodies) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Protein Summary

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

MDS1 and EVI1 complex locus (MECOM) antibody
MDS1 and EVI1 complex locus (Mecom) antibody
MDS1 and EVI1 complex locus (mecom) antibody
MDS1 and EVI1 complex locus L homeolog (mecom.L) antibody

AML1-EVI-1 antibody
D630039M04Rik antibody
evi-1 antibody
evi1 antibody
im:7140716 antibody
Jbo antibody
Mds antibody
Mds1 antibody
Mds1-Evi1 antibody
mecom antibody
mecom-a antibody
mecom-b antibody
prdm3 antibody
xEvi-1 antibody
Znfpr1b1 antibody

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID	SPECIES
2122	Homo sapiens
424997	Gallus gallus
532209	Bos taurus
14013	Mus musculus
497407	Danio rerio
460837	Pan troglodytes
488148	Canis lupus familiaris
698603	Macaca mulatta
100343228	Oryctolagus cuniculus
100403987	Callithrix jacchus
100591579	Nomascus leucogenys
294924	Rattus norvegicus
734157	Xenopus laevis

Selected quality suppliers for anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies

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Phone:	+1 877 302 8632
Fax:	+1 888 205 9894 (Toll-free)
E-Mail:	orders@antibodies-online.com

Show all anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies with Pubmed References