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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane.
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DENR (show DENR ELISA Kits) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (show EIF1 ELISA Kits)/eIF2 (show EIF2S1 ELISA Kits)/eIF3 (show EIF3A ELISA Kits) binding, thus operating in post-termination ribosome recycling and translation re-initiation
Reinitiation complexes involving initiation factors eIF2D, MCT-1 (show CMA1 ELISA Kits), and DENR (show DENR ELISA Kits) controls the translation of a large fraction of mammalian cellular mRNAs.
Overexpression of MCT1 (show CMA1 ELISA Kits) is associated with gliomas.
MCT-1 (show CMA1 ELISA Kits) is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis.
The present study indicates possible involvement of a protein kinase (show CDK7 ELISA Kits) (PK)C- and PKA-mediated pathway associated with expression of MCT1 (show CMA1 ELISA Kits) and lactate transport in rhabdomyosarcoma cells.
The oppositions between MCT-1 (show CMA1 ELISA Kits) and p53 (show TP53 ELISA Kits) are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression
The result suggest that co-expression of CD147 and MCT1 (show CMA1 ELISA Kits)/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC.
Results describe the expression and purification of MCT-1 (show CMA1 ELISA Kits) in insect cells using a baculovirus expression system.
tumor cell lines overexpressing MCT-1 (show CMA1 ELISA Kits) exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation
demonstrated the presence of sequence-specific DNA-binding protein (show UBE2V1 ELISA Kits) in nuclear extracts designated as LMBF; the 26-mer (show MERTK ELISA Kits) oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 (show CMA1 ELISA Kits) promoter
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A