Matrix Metallopeptidase 1 (Interstitial Collagenase) Proteins (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP1 Antibodies (324) and MMP1 Kits (129) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP1 4312 P03956
MMP1 17386 P33435
MMP1 300339  
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Top MMP1 Proteins at

Showing 10 out of 44 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
HEK-293 Cells Human His tag Human MMP-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 10 μg Log in to see 12 to 15 Days
Human Human Un-conjugated 10 μg Log in to see 6 to 7 Days
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
HEK-293 Cells Human Un-conjugated   10 μg Log in to see 10 to 12 Days

MMP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced MMP1 Proteins

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 Pubmed References

More Proteins for Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaction Partners

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. cabozantinib suppressed MMP1 expression by blocking HGF (show HGF Proteins)-MET signaling and that HGF (show HGF Proteins)-MET-MMP1 signaling is involved in the invasiveness and proliferation of BCa (show BLNK Proteins) cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa (show BLNK Proteins).

  2. rs1144393 in the MMP1 promoter region can be a predictor of grade >/= 2 RILI in lung cancer patients treated with thoracic radiation.

  3. The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1, MMP3 (show MMP3 Proteins) and MMP13 (show MMP13 Proteins) via MAPK (show MAPK1 Proteins) pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.

  4. proteolysis of collagen-rich natural extracellular matrix (ECM (show MMRN1 Proteins)), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM (show MMRN1 Proteins) morphology, viscoelastic properties, and molecular composition.

  5. SAA1 (show SAA1 Proteins) can be a potential mediator for UV-induced MMP-1 expression in human skin.

  6. collagen II-activated phosphorylated-DDR2 (show DDR2 Proteins) induces CYR61 (show CYR61 Proteins) through activation of transcription factor activator protein 1 (AP-1 (show FOSB Proteins)). The elevated CYR61 (show CYR61 Proteins), in turn, accelerates MMP1 production via ETS1 (ETS (show ETS1 Proteins) proto-oncogene (show RAB1A Proteins) 1).

  7. M. tuberculosis infection caused enhanced MMP-1, -9, and miR-223 expression, with inhibited BMAL1 expression. MiR-223 modulated BMAL1 expression via the direct binding of BMAL1 3'-UTR.

  8. 20(S)-PPD (show HPD Proteins) treatment modulated MMP-1 mRNA expression and the transcriptional activity of activator protein (AP)-1 (show FOSB Proteins), a major transcription factor of MMP-1.

  9. This is the first study to indicate that the genotypes of MMP1 promoter -1607, do not significantly confer susceptibility to lung cancer in a Taiwanese population.

  10. Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD (show CHDH Proteins) before and after myocardial revascularization.

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. the identification of MMP1 and MMP10 (show MMP10 Proteins) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1, MMP-3 (show MMP3 Proteins), and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

  2. Data indicate that matrix metalloproteinases mmp1 and mmp2 (show MMP2 Proteins) mutants have distinct heart phenotypes.

  3. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  4. A primary function of Mmp1, under the control of the JNK (show MAPK8 Proteins) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  5. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (show GUSB Proteins) homeostasis

  6. Study identified three genes, regeneration (rgn (show RGN Proteins)), augmenter of liver regeneration (alr (show GFER Proteins)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. that MMP-13 (show MMP13 Proteins) is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

  2. the phenotype seen in the Hdac4 (show HDAC5 Proteins)(-/-) mice is partially derived from elevation in MMP-13 (show MMP13 Proteins) and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

  3. MEF2C (show MEF2C Proteins) is necessary for Mmp13 (show MMP13 Proteins) gene expression at the transcriptional level and participates in PTH (show PTH Proteins)-stimulated Mmp13 (show MMP13 Proteins) gene expression by increased binding to c-FOS at the AP-1 (show JUN Proteins) site in the Mmp13 (show MMP13 Proteins) promoter.

  4. data reveal a novel involvement of MMP-13 (show MMP13 Proteins) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 Proteins) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A Proteins)(+) T-cell response in vitro; MMP-13 (show MMP13 Proteins) might be a promising target for therapeutic intervention in inflammatory diseases

  5. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 Proteins)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 Proteins) and matrix metalloproteinase 13 (show MMP13 Proteins).

  6. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Proteins) with an inducible Col2a1 (show COL2A1 Proteins)-Cre caused premature production of pErk1/2 and Mmp13 (show MMP13 Proteins) in the growth plate.

  7. Mmp13 (show MMP13 Proteins) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Proteins), and Osterix (show SP7 Proteins) through distal enhancers.

  8. Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Proteins) in OA and highlights the HIF1alpha (show HIF1A Proteins)-beta-catenin (show CTNNB1 Proteins) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  9. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (show F2R Proteins) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  10. IL-1Ra (show IL1RN Proteins) is associated with MMP-13 (show MMP13 Proteins) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (show RBM9 Proteins), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

  2. The expression patterns of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (show MMP2 Proteins), and MMP8 (show MMP8 Proteins) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  3. Data suggest that luteolytic factors (such as interferon gamma (show IFNG Proteins), tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  4. The results showed that a decrease in MMP-1 and MMP-2 (show MMP2 Proteins) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  6. MMP-1 promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB (show NFKB1 Proteins)

  7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (show MMP14 Proteins) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (show MMP2 Proteins)

  9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (show MMP13 Proteins) (follicular apex (show APEX1 Proteins) vs. base) for the preovulatory collagenolysis required for follicle rupture

  10. identification of MT1-MMP (show MMP14 Proteins) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. These results suggest that PEP-1-SIRT2 (show SIRT2 Proteins) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 Proteins) signaling in articular chondrocytes. .

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (show TIMP3 Proteins) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. ANXA2 (show ANXA2 Proteins) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (show IL8 Proteins) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

MMP1 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MMP1

  • matrix metallopeptidase 1 (MMP1)
  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 S homeolog (mmp1.S)
  • interstitial collagenase (MMP-1)
  • interstitial collagenase (LOC100727966)
  • matrix metallopeptidase 1 (Mmp1)
  • CG4859 protein
  • Clg protein
  • Clgn protein
  • col4 protein
  • dm1-MMP protein
  • Dmel\\CG4859 protein
  • dmmp1 protein
  • l(2)k04809 protein
  • MMP-1 protein
  • MMP-13 protein
  • Mmp1 protein
  • Mmp 1 protein
  • Mmp1a protein
  • mmp18 protein

Protein level used designations for MMP1

fibroblast collagenase , interstitial collagenase , matrix metalloprotease 1 , matrix metalloproteinase 1 , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , matrix metalloproteinase-1 , CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , Collagenase-3 , collagenase 3 , collagenase-1 , matrix metalloproteinase 13 , matrix metalloproteinase-13 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , matrix metallopeptidase 1a , matrix metalloproteinase 1a (interstitial collagenase) , myocardial collagenase

4312 Homo sapiens
397320 Sus scrofa
37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
17386 Mus musculus
281308 Bos taurus
100009110 Oryctolagus cuniculus
489428 Canis lupus familiaris
100033896 Equus caballus
495287 Xenopus laevis
443463 Ovis aries
101120355 Ovis aries
100727966 Cavia porcellus
300339 Rattus norvegicus
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