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The protein encoded by MBD1 is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). Additionally we are shipping MBD1 Antibodies (103) and MBD1 Kits (5) and many more products for this protein.
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Human MBD1 Protein expressed in Wheat germ - ABIN1310462
Jin, Kadam, Pfeifer: Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. in Nucleic acids research 2010
MBD1 (show DPEP1 Proteins) may be a tumor suppressor gene in advanced colorectal cancer (CRC (show CALR Proteins))and affect the development and metastasis of CRC (show CALR Proteins) by regulating 8 tumor suppressor genes through binding with SP1 (show PSG1 Proteins).
Our findings imply that reduced stability and enhanced dynamics of MBD1 (show DPEP1 Proteins) or MBD6 is the origin of ATP7B (show ATP7B Proteins) dysfunction in Wilson disease patients with the G85V or G591D mutation.
MBD1 (show DPEP1 Proteins) regulates localization and activity of Tet1 (show TET1 Proteins) in a CXXC3 domain-dependent manner.
the binding of MBD1 (show DPEP1 Proteins) to nucleosomes demonstrates sequence preferences depending on the position of the methyl groups on the nucleosome.
c-myc (show MYC Proteins) plays a key role in MBD1 (show DPEP1 Proteins) mediated epigenetic silencing of KEAP1 (show KEAP1 Proteins).
Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 (show DPEP1 Proteins) protein.
MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 Proteins)) gene polymorphisms and schizophrenia.
We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 (show DPEP1 Proteins) protein complex in maintaining central tolerance
an important function of MBD1 (show DPEP1 Proteins) in DNA repair and mediation of chemoradioresistance of cancer cells
MBD1 (show DPEP1 Proteins) has a role in neural stem cell maintenance and epigenetic regulation.
H19 (show NCKAP1 Proteins) lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1 (show DPEP1 Proteins).
regulatory loop formed by MBD1 (show DPEP1 Proteins) and miR (show MLXIP Proteins)-195 is an important component of the epigenetic network that controls aNSC fate
MBD1 (show DPEP1 Proteins), miR (show MLXIP Proteins)-184, and Numbl (show NUMBL Proteins) form a regulatory network that helps control the balance between proliferation and differentiation of adult neural stem/progenitor cells.
Results indicate that MBD1 (show DPEP1 Proteins) can interpret the CpG dinucleotide as a repressive signal in vivo regardless of its methylation status.
These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE (show MAGEB10 Proteins)-A genes.
Mbd1 (show DPEP1 Proteins)(-/-) mice exhibit several core deficits associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity.
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions\; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides\; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
CXXC-type zinc finger protein 3
, methyl-CpG binding domain protein 1 isoform PCM1
, methyl-CpG-binding domain protein 1
, protein containing methyl-CpG-binding domain 1
, the regulator of fibroblast growth factor 2 (FGF-2) transcription
, methyl-CpG-binding protein MBD1
, coiled-coil domain containing 11