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The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family. Additionally we are shipping MAP4K4 Antibodies (150) and MAP4K4 Kits (2) and many more products for this protein.
Showing 6 out of 6 products:
an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4 (show CD4 Proteins)+ T cells through MAP4K4 expression.
the close proximity between AcSDKP and FGFR1 (show FGFR1 Proteins) was essential for the suppression of TGFbeta (show TGFB1 Proteins)/smad (show SMAD1 Proteins) signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.
RBM4 (show RBM4 Proteins)-SRSF3 (show SRSF3 Proteins)-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 (show MAPK8 Proteins) signaling pathway.
these findings identify MAP4K4 as a novel MAPK/ERK (show MAPK1 Proteins) pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance.
This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes
Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM
Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D.
MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells
miR (show MLXIP Proteins)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4
Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.
These results demonstrate that protein kinase (show CDK7 Proteins) Map4k4 drives obesity-induced hyperinsulinemia and insulin (show INS Proteins) resistance in part by promoting insulin (show INS Proteins) secretion from beta cells in mice.
These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.
Mice with Map4k4 deleted in Myf5 (show MYF5 Proteins)-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin (show INS Proteins) resistance.
HGK/MAP4K4 deficiency has a role in inducing TRAF2 (show TRAF2 Proteins) stabilization and Th17 differentiation leading to insulin (show INS Proteins) resistance
microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2
MAP4K4 is essential for CD4 (show CD4 Proteins)+ T cell proliferation and activation in vitro through suppressing PKC-theta (show PRKCQ Proteins) activation.
Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 (show SREBF1 Proteins) in an AMPK (show PRKAA1 Proteins)- and mTOR (show FRAP1 Proteins)-dependent but JNK (show MAPK8 Proteins)-independent mechanism.
study identified single nucleotide polymorphisms at different locations of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene of cattle and several of them were significantly associated with the somatic cell score and other different milk traits
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
HPK/GCK-like kinase HGK
, MAPK/ERK kinase kinase kinase 4
, MEK kinase kinase 4
, Ste20 group protein kinase HGK
, hepatocyte progenitor kinase-like/germinal center kinase-like kinase
, nck-interacting kinase
, MEKKK 4
, NCK interacting kinase
, mitogen activated protein kinase kinase kinase kinase 4