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Histone methyltransferase that plays an essential role in early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 Kits (10) and many more products for this protein.
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Collectively, these data indicated that ATR (show ATR Antibodies) or ATM (show ATM Antibodies) inhibition represent potential therapeutic strategies for the treatment of AML (show RUNX1 Antibodies), especially MLL (show MLL Antibodies)-driven leukemias.
Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL (show MLL Antibodies)-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.
NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies) interacts with MLL (show MLL Antibodies) via the NUP98 (show NUP98 Antibodies) second FG repeat domain. In the absence of MLL (show MLL Antibodies) (in knockout mice), NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies)-induced cell immortalization and leukemogenesis are severely inhibited. MLL (show MLL Antibodies) is important for the recruitment of NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies) to the HOXA locus and for NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies)-induced HOXA gene expression. MLL (show MLL Antibodies) is crucial for NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies) leukemia initiation.
Atg5 (show ATG5 Antibodies)-dependent autophagy contributes to the development of acute myeloid leukemia (show BCL11A Antibodies) in an MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-driven mouse model.
These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Antibodies) and DOT1L (show DOT1L Antibodies) and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL Antibodies) fusion-AF4 complex and DOT1L (show DOT1L Antibodies) for more effective treatment of MLL (show MLL Antibodies)-rearranged leukemia.
This study demonstrated that Kmt2a (show MLL Antibodies) regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.
Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
HoxBlinc RNA Recruits Set1 (show SETD1A Antibodies)/MLL (show MLL Antibodies) Complexes to Activate Hox (show MSH2 Antibodies) Gene Expression Patterns and Mesoderm Lineage Development.
MLL1 and DOT1L (show DOT1L Antibodies) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
, histone-lysine N-methyltransferase MLL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
, myeloid/lymphoid or mixed-lineage leukemia 1
, histone-lysine N-methyltransferase 2A
, lysine N-methyltransferase 2A
, myeloid/lymphoid or mixed-lineage leukemia protein 1
, trithorax Drosophila
, zinc finger protein HRX