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NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Kits (8) and and many more products for this protein.
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identified a novel endogenous role for human NAT1 (show EIF4G2 Antibodies) that might explain some of its effects in cancer cell growth and survival
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Antibodies) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Antibodies) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 Antibodies) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Antibodies) alleles imputed as fast acetylator genotypes. [meta-analysis]
NAT1 (show EIF4G2 Antibodies) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
NAT1 (show EIF4G2 Antibodies) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.
NAT1 (show EIF4G2 Antibodies) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.
We report that miR (show MLXIP Antibodies)-1290 directly targets the NAT1 (show EIF4G2 Antibodies) 3'-UTR (show UTS2R Antibodies) and that NAT1 (show EIF4G2 Antibodies) protein expression is correlated with improved OS of breast cancer patients.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
Candidate gene NAT1 (show EIF4G2 Antibodies) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.
Data suggest that NAT1 (show EIF4G2 Antibodies)/NAT2 (show SLC38A1 Antibodies) participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
, N-acetyltransferase (arylamine N-acetyltransferase)
, N-acetyltransferase 1 (arylamine N-acetyltransferase)
, N-acetyltransferase type 1
, arylamide acetylase 1
, arylamine N-acetyltransferase 1
, monomorphic arylamine N-acetyltransferase