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Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Additionally we are shipping NIMA (Never in Mitosis Gene A)- Related Kinase 9 Antibodies (144) and NIMA (Never in Mitosis Gene A)- Related Kinase 9 Kits (3) and many more products for this protein.
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High expression level of NEK9 is associated with recurrence in glioblastoma.
Signaling cascade of the NIMA-related kinases (Neks) Nek6 (show NEK6 Proteins), Nek7 (show NEK7 Proteins), and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 (show KIF20A Proteins) and Kif14 (show KIF14 Proteins) to properly coordinate cytokinesis.
Recessive NEK9 mutation is associated with lethal skeletal dysplasia.
Somatic Mutations in NEK9 Cause Nevus Comedonicus.
Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 (show TP53 Proteins) target gene expression.
The C-terminal domain of Nek9 activates Nek7 (show NEK7 Proteins) through promoting back-to-back dimerization.
The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53 (show TP53 Proteins).
NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint (show BUB3 Proteins) control.
Structural analysis of LC8 (show DYNLL1 Proteins) with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 (show DYNLL1 Proteins) upon phosphorylation on Ser (show SIGLEC1 Proteins)(944) within the Nek9 sequence
Nek9 phosphorylates NEDD1 (show NEDD1 Proteins) on Ser377 driving its recruitment and thereby that of gamma-tubulin (show TUBG1 Proteins) to the centrosome in mitotic cells.
NEK9 is a critical component of the replication stress response that promotes CHK1 (show CHEK1 Proteins) activity, maintaining genome integrity following challenges to DNA replication.
Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin (show TUBG1 Proteins) and resulted in retention of the spindle assembly checkpoint protein Bub3 (show BUB3 Proteins) at the kinetochores.
Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).
NIMA (never in mitosis gene a)- related kinase 9
, NIMA-related kinase Nek8
, nercc1 kinase
, never in mitosis A-related kinase 9
, nimA-related kinase 8
, nimA-related protein kinase 9
, serine/threonine-protein kinase Nek9
, NIMA-related kinase 8
, serine/threonine-protein kinase Nek9-like
, NIMA-family kinase Nercc1