Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 Proteins (NEDD8)

displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. Additionally we are shipping NEDD8 Antibodies (129) and NEDD8 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEDD8 4738 Q15843
NEDD8 18002 P29595
NEDD8 25490 Q71UE8
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Top NEDD8 Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Human His tag,SUMO Tag   50 μg Log in to see 4 Days
$88.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,101.00
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,101.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,101.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,046.15
Details

NEDD8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, , , , , , , , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Interaction Partners

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (show TGFB1 Proteins) signaling pathways.

  2. NEDD8-mediated neddylation promotes stress granule assembly.

  3. NEDD8 seems to inhibit the Src (show SRC Proteins)-mediated phosphorylation of caveolin-1 (show CAV1 Proteins) by modifying the structure of caveolin-1 (show CAV1 Proteins) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.

  4. The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (show TP53 Proteins) status.

  5. Here we report that high expression of neddylation components, NEDD8 and NAE1 (show NAE1 Proteins), are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence

  6. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  7. Furthermore, the authors characterized SENP8/DEN1 (show SENP8 Proteins) as the protease that counteracts Ubc12 (show ube2m Proteins) auto-neddylation, and observed aberrant neddylation of Ubc12 (show ube2m Proteins) and other NEDD8 conjugation pathway components in SENP8 (show SENP8 Proteins)-deficient cells.

  8. MKK7 (show MAP2K7 Proteins) undergoes neddylation in human breast cancer cells

  9. complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (show IL31RA Proteins) regulator Cand1 (show CAND1 Proteins).

  10. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  2. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  3. neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (show CUL5 Proteins) is required for its interaction with TRAF6 (show TRAF6 Proteins).

  4. Our findings provide mechanistic evidence of the effects of IAP (show ALPI Proteins) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.

  5. a role of Nedd8 in regulating caspase-1 (show CASP1 Proteins) activation following inflammasome activation

  6. Nedd8 and its associated E2 carrier protein (Ubc12 (show ube2m Proteins)) and E3-SCF (show KITLG Proteins) ligase play a key role in regulating the expression and activity of ENaC (show SCNN1A Proteins) in alveolar pneumocytes.

  7. a new regulatory mechanism of RCAN1 (show RCAN1 Proteins) function

  8. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.

  9. The NEDD8 pathway appears to play an important role in CD4 (show CD4 Proteins)+ T-cell-mediated inflammatory responses

  10. Nedd8 and AhR (show AHR Proteins) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis

Fruit Fly (Drosophila melanogaster) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. the Cul1 (show CUL1 Proteins)-based SCF (show KITLG Proteins) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (show CCNE1 Proteins) in vivo

  2. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (show SENP8 Proteins) is crucial for animal viability.

NEDD8 Protein Profile

Protein Summary

displays differential expression after induction by nerve growth factor

Gene names and symbols associated with NEDD8

  • neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)
  • neural precursor cell expressed, developmentally down-regulated gene 8 (Nedd8)
  • neural precursor cell expressed, developmentally down-regulated 8 (Nedd8)
  • CG10679 gene product from transcript CG10679-RB (Nedd8)
  • neural precursor cell expressed, developmentally down-regulated 8 (nedd8)
  • Nedd8 (Nedd8)
  • ubiquitin-like protein Nedd8 (nedd8)
  • neural precursor cell expressed, developmentally down-regulated 8 L homeolog (nedd8.L)
  • CG10679 protein
  • DDBDRAFT_0218116 protein
  • DDBDRAFT_0238041 protein
  • DDB_0218116 protein
  • DDB_0238041 protein
  • Dmel\\CG10679 protein
  • dNEDD8 protein
  • GB17785 protein
  • NEDD-8 protein
  • nedd8 protein
  • nedd8.S protein
  • Rub1 protein
  • si:zc14a17.5 protein
  • ubiquitin protein

Protein level used designations for NEDD8

neddylin , ubiquitin-like protein Nedd8 , NEDD-8 , NEDD8 , neural precursor cell expressed developmentally down-regulated protein 8 , neural precursor cell expressed, developmentally down-regulated gene 8 , CG10679-PA , Nedd8-PA , neural precursor cell-expressed developmentally downregulated , neural precursor cell expressed, developmentally down-regulated 8 , Nedd8 , NEDD8 protein , neural precursor cell expressed, developmentally down-regulated 8 S homeolog

GENE ID SPECIES
4738 Homo sapiens
18002 Mus musculus
25490 Rattus norvegicus
35151 Drosophila melanogaster
286796 Bos taurus
368667 Danio rerio
480265 Canis lupus familiaris
549727 Xenopus (Silurana) tropicalis
552822 Apis mellifera
715763 Macaca mulatta
8621655 Dictyostelium discoideum AX4
100009008 Oryctolagus cuniculus
100301786 Oncorhynchus mykiss
100528101 Ictalurus punctatus
100520086 Sus scrofa
446966 Xenopus laevis
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