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The protein encoded by NOSIP may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Additionally we are shipping NOSIP Antibodies (47) and NOSIP Kits (9) and many more products for this protein.
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Nosip is a novel factor critical for neural stem cell/progenitor self-renewal and neurogenesis during mouse and Xenopus development.
NOSIP mediates the monoubiquitination of the PP2A (show PPP2R2B Proteins) catalytic subunit and the loss of NOSIP results in an increase in PP2A (show PPP2R2B Proteins) activity in craniofacial tissue in NOSIP knockout mice.
While NOSIP expression was increased in Hirschsprung's disease (HSCR (show EDNRB Proteins)) vs. non- HSCR (show EDNRB Proteins) patients, no significant difference was observed in patients with Hirschsprung's associated enterocolitis. The increased expression of NOSIP in the aganglionic and ganglionic bowel of HSCR (show EDNRB Proteins) may contribute to the development of enterocolitis by inhibiting local nitric oxide production in patients with Hirschsprung's disease.
Endogenous NOSIP reduces the enzymatic capacity of eNOS, specifically in the G(2) phase of the cell cycle by targeting eNOS to the actin cytoskeleton.
endothelial nitric oxide synthase (eNOS (show NOS3 Proteins)) interacting protein (NOSIP), modulator of eNOS (show NOS3 Proteins) activity by alteration of eNOS (show NOS3 Proteins) subcellular localisation; high expression levels in endothelial cells and vascularized tissue.
Hydrogen peroxide down regulates endothelial dihydrofolate reductase (show DHFR Proteins) expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 Proteins) dysfunction.
Cdc37 (show CDC37 Proteins) has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS (show NOS3 Proteins)) and may play an important role in mediating the eNOS (show NOS3 Proteins) protein complex formation.
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
nitric oxide synthase interacting protein
, eNOS interacting protein
, nitric oxide synthase-interacting protein
, eNOS-interacting protein