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NCOA5 encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. Additionally we are shipping NCOA5 Antibodies (28) and and many more products for this protein.
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knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT (show ITK Proteins)) in hepatocellular carcinoma cells.
NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.
suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC (show FAM126A Proteins), partially by increasing IL-6 (show IL6 Proteins) expression
NCOA5 functions as an LXR (show NR1H3 Proteins) corepressor.A central role for NCOA5 in mediating crosstalk between pro-inflammatory and anti-inflammatory pathways that results in repression of macrophage cholesterol efflux.
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.
nuclear receptor coactivator 5
, Nuclear receptor coactivator 5
, coactivator independent of AF-2