anti-Plectin (PLEC) Antibodies

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Additionally we are shipping Plectin Kits (16) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLEC 5339 Q15149
PLEC 18810 Q9QXS1
PLEC 64204  
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Top anti-Plectin Antibodies at

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Plectin Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PLEC using Jurkat whole  lysates. 100 μL 11 to 12 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant PLEC, Human. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
Human Rabbit Un-conjugated IHC (p)   100 μL 11 to 13 Days
Human Mouse Un-conjugated ELISA, WB   100 μg 11 to 14 Days
Human Guinea Pig Un-conjugated IHC, IHC (fro), IHC (p), WB   100 μL 11 to 14 Days
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged PLEC1 is 0.1 ng/ml as a capture antibody. Western Blot detection against Immunogen (37.84 KDa) . 100 μg 11 to 12 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL 11 to 12 Days
Human Mouse Un-conjugated IHC, IHC (fro), WB   50 μg 11 to 14 Days
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of recombinant Human PLEC. IHC-P analysis of Human Tissue, with DAB staining. 100 μg 11 to 18 Days

Top referenced anti-Plectin Antibodies

  1. Human Monoclonal PLEC Primary Antibody for ICC, IHC (fro) - ABIN265852 : Domke, Franke et al.: The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic ... in Cell and tissue research 2019 (PubMed)

  2. Fish Polyclonal PLEC Primary Antibody for IHC (fro), IF - ABIN113466 : Liu, Wu, Lin, Liu, Chen: [Fusion expression of SLT-IIeB gene and FedF gene of Ee in Escherichia coli and its immunogenicity] in Wei sheng wu xue bao = Acta microbiologica Sinica 2008 (PubMed)

More Antibodies against Plectin Interaction Partners

Human Plectin (PLEC) interaction partners

  1. 40/359 arrhythmogenic right ventricular cardiomyopathy (ARVC) patients carried 1+ rare PLEC variants but rare variants also seem to occur frequently in the control population and no difference was found in the prevalence of rare PLEC variants in ARVC patients with/without desmosomal likely pathogenic/pathogenic variant. Decreased plectin junctional localization in myocardial tissue was found in 5 variant ARVC patients.

  2. Three of them [PLEC (OR = 6.28, p = 6.42 x 10(-23) ) (p.Arg2016Trp), EXO5 (OR = 3.37, p = 4.82 x 10(-09) ) (p.Arg344AlafsTer10) and DNAH7 (OR = 1.64, p = 0.048)] were replicated as potential candidates.

  3. The study has identified two mutations in two large consanguineous pedigrees. Identification of novel variants in the LAMA3 and PLEC genes will expand the mutation spectrum and also help in genetic counselling of patients in the Pakistani population.

  4. These findings extend current knowledge of the mutation spectrum of the PLEC gene associated with limbgirdle muscular dystrophy 2Q.

  5. The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape.

  6. We present two cases of Epidermolysis bullosa with significant urologic involvement resulting from mutations in plectin.

  7. lectin and cytoskeletons were not detected in the nuclei of liver cells compared to the results of confocal microscopy. Despite the absence of nuclear plectin and cytoskeletal filaments, the evidence provided support that nuclear pleomorphism of cancer cells is correlated with the cytoplasmic disorganization of cytoskeleton.

  8. data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.

  9. The dominant expression of the P1a isoform in epidermal basal cell layer and cultured keratinocytes suggests that mutations in the first exon of isoform 1a cause skin-only epidermolysis bullosa simplex without extracutaneous involvement.

  10. Report of a non-consanguineous Iranian family with two affected sisters showing limb-girdle muscular dystrophy and myasthenic symptoms without any skin involvement, caused by plectinopathy.

  11. plectin interacts with keratins 5 and 14 in a process associated with epidermolysis bullosa simplex

  12. Six of sicteen epidermolysis bullosa simplex probands had dominant PLEC missense mutations.

  13. Mislocated Plectin is necessary for exosome formation and produces exosomes that are capable of promoting pancreatic tumor growth and aggression.

  14. this study is the first to demonstrate that up-regulation of vimentin and plectin expression positively correlates with the invasion and metastasis of androgen-independent PCA

  15. the potential importance of the endophilin B2-plectin complex in the biological functions depending on nuclear migration and positioning.

  16. results confirm epidermolysis bullosa simplex-pyloric atresia is linked to mutations in distal exons 1-30 and 32 of PLEC; while epidermolysis bullosa simplex-muscular dystrophy is linked to PLEC mutations in all exons, in most cases one of the mutations affects exon 31

  17. findings suggest that plectin promotes the migration and invasion of head and neck squamous cell carcinoma (HNSCC) cells through activation of Erk 1/2 kinase and is a potential prognostic biomarker of HNSCC.

  18. mutational analysis of PLEC1 revealed a homozygous 36 nucleotide insertion (1506_1507ins36) that results in a reduced expression of PLEC1 mRNA and plectin in patients with epidermolysis bullosa simplex and congenital myasthenic syndrome.

  19. A linker region in the COOH-terminal end and serine residue at position 4645 may be important for the binding of plectin to intermediate filaments.

  20. The novel FUS-plectin interaction offers new perspectives for understanding the role of FUS and plectin mutations in the pathogenesis of FUS associated diseases

Mouse (Murine) Plectin (PLEC) interaction partners

  1. data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.

  2. Data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice.

  3. results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways.

  4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin beta 4 disrupts the complex, resulting in disassembly of hemidesmosomes.

  5. Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner.

  6. the lack of plectin has divergent implications on biomechanical properties depending on the respective cell type.

  7. Ablation of plectin in myelinating Schwann cells is found not to affect myelin sheath formation.

  8. Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells.

  9. findings suggest a mechanism for microtubule(MT)destabilization in which isoform-specific binding of P1c to MTs antagonizes the MT-stabilizing and assembly-promoting function of MT-associated proteins through an inhibitory function exerted by plectin's SH3 domain

  10. plectin 1a, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that degradation of hemidesmosome-anchored plectin is spatially controlled.

  11. two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages

  12. Mature focal adhesions and their derivative fibronectin fibril-aligned fibrillar adhesions (FbAs) serve as docking sites for vimentin intermediate filaments (IFs) in a plectin isoform 1f (P1f)-dependent manner.

  13. BPAG1-b was detectable in vitro and in vivo as a high molecular mass protein in striated and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin.

  14. plectin binds to Fer kinase

  15. Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes

  16. dermal fibroblasts isolated from plectin 1-deficient mice exhibited abnormalities in their actin cytoskeleton

  17. Here we present data on the expression of plectin rodless isoforms in mouse brain and in rat glioma C6 cells on RNA and protein levels.

  18. Data show that, in differentiated mouse myotubes, plectin binds to the regulatory gamma1 subunit of AMP-activated protein kinase (AMPK), the key regulatory enzyme of energy homeostasis.

  19. These data establish a link between cytolinker-controlled cytoarchitecture/scaffolding functions of keratin IFs and specific MAP kinase cascades mediating distinct cellular responses.

  20. endogenous plectin is nitrosylated in vivo, NO donor-induced intermediate filament collapse proceeds faster in plectin-deficient compared with wild-type cells; its affinity for vimentin, however, is higher in a reduced, more relaxed conformation

Plectin (PLEC) Antigen Profile

Protein Summary

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Gene names and symbols associated with anti-Plectin (PLEC) Antibodies

  • plectin (LOC100481602) antibody
  • plectin L homeolog (plec.L) antibody
  • plectin (PLEC) antibody
  • plectin (Plec) antibody
  • plectin (LOC786966) antibody
  • AA591047 antibody
  • AU042537 antibody
  • EBS1 antibody
  • EBSO antibody
  • HD1 antibody
  • IFAP300 antibody
  • LGMD2Q antibody
  • Pcn antibody
  • Plec1 antibody
  • PLEC1b antibody
  • Plectin-1 antibody
  • Pltn antibody

Protein level used designations for anti-Plectin (PLEC) Antibodies

plectin , plectin-1-like , hemidesmosomal protein 1 , plectin 1, intermediate filament binding protein 500kDa , plectin-1 , plectin 1 , plectin-6 , 300 kDa intermediate filament-associated protein

100481602 Ailuropoda melanoleuca
398587 Xenopus laevis
5339 Homo sapiens
18810 Mus musculus
64204 Rattus norvegicus
100682530 Cricetulus griseus
786966 Bos taurus
482083 Canis lupus familiaris
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