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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNAB2 Antibodies (52) and and many more products for this protein.
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The results show that KvBeta 2 dysregulation of Kv4.3 is involved in the pathogenesis of Brugada Syndrome. This new finding also expands the list of genes associated with susceptibility to BrS and may contribute to improve molecular diagnosis of this cardiac arrhythmia disorder.
Results identified gain and loss of function mutations which lead to increased and decreased potassium currents enhancing AF.
Incretin regulation of beta-cell function involves the acetylation of Kv beta2.
Article reports a newly identified protein-protein interaction between the postsynaptic density-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
the association of a Kvbeta subunit with TRPV1 channels, is reported.
This study demonistrated that loss of Kvbeta2 likely contributes to the cognitive and neurological impairments observed in 1p36DS patients.
investigation of in vivo function
strain differences significantly affected survival, body weight and thermoregulation in Kv beta2-null mice
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
potassium voltage-gated channel, shaker-related subfamily, beta member 2
, K(+) channel subunit beta-2
, potassium channel beta 2 subunit
, voltage-gated potassium channel subunit beta-2
, putative potassium channel beta-subunit
, K+ channel beta-2 subunit
, potassium channel shaker chain beta 2
, potassium channel protein beta subunit
, potassium channel
, potassium channel Kv beta 2.1 subunit
, neuroimmune protein F5
, potassium voltage gated channel, shaker related subfamily, beta member 2