anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) Antibodies

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNH1 3756 O95259
KCNH1 16510 Q60603
KCNH1 65198 Q63472
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Top anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Western blot analysis of Kv10.1 expression in HeLa (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry: KCNH1 Antibody [NBP1-84935] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells. Immunocytochemistry/Immunofluorescence: KCNH1 Antibody [NBP1-84935] - Staining of human cell line U-2 OS shows positivity in plasma membrane, cytoplasm & nucleus but excluded from the nucleoli. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275384 staining HuvEc by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of KCNH1 using anti-KCNH1 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human COLO-320 cell lysate, Lane 2: human HepG2 cell lysate, Lane 3: human A549 cell lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-KCNH1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for KCNH1 at approximately 150KD. The expected band size for KCNH1 is at 111KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IHC Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Brain Tissue using Kv10.1 Rabbit Polyclonal Antibody diluted at 1:200. Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain Tissue using Kv10.1 Rabbit Polyclonal Antibody diluted at 1:200. 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Antibodies

  1. Human Polyclonal KCNH1 Primary Antibody for IHC - ABIN966446 : Occhiodoro, Bernheim, Liu, Bijlenga, Sinnreich, Bader, Fischer-Lougheed: Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. in FEBS letters 1998 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 Interaction Partners

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. phosphatidylinositol 4,5-bisphosphate has dual effects on hEAG1 channels and its action as activator or inhibitor depends on its initial level on the plasma membrane.

  2. the overexpression of Eag1 might be associated with an increased risk of progression to breast cancer

  3. A role of Kv10.1 in coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base is proposed [REVIEW].

  4. in this report, we present two independent screening campaigns in which we wanted to identify small molecules that bind to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim (PAS) domain from the human EAG-related gene (ERG) channel or the amino or carboxy terminal globular domains from the mouse EAG1 channel, affecting their interaction.

  5. REVIEW: Kv10.1 potassium channel: role from the brain to the tumors

  6. Data show that the interaction of beta1 integrins with hERG1 channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 and affected different aspects of tumor progression.

  7. Crystal structure of the PAS domain of the hEAG potassium channel has been presented.

  8. KV10.1 localizes to the centrosome and the primary cilium and promotes ciliary disassembly. Interference with KV10.1 ciliary localization abolishes not only the effects on ciliary disassembly, but also KV10.1-induced tumor progression in vivo Conversely.

  9. Mibefradil binds to the voltage sensor domain of Kv10.1 channels, modifying the gating of the channels in a way that in some, but not all, aspects opposes the gating effects exerted by divalent cations.

  10. Eag1 potassium channels and miR34a are involved in the response to rotenone-induced injury in SHSY5Y cells.

  11. Simulations with the inactivation-enhancing mutant Y464A or Na(+) ions lead to trapped water molecules behind the SF, suggesting that these simulations captured early conformational changes linked to C-type inactivation

  12. The human EAG1 (hEAG1) channel is remarkably sensitive to inhibition by intracellular calcium (Ca(2+) i) through binding of Ca(2+)-calmodulin to three sites adjacent to the eagD and cNBHD.

  13. Structural, biochemical, and functional analysis of the calmodulin (CaM) binding sites within the EAG1 channel suggests that the molecular change induced by CaM and underlying channel inhibition occurs locally.

  14. Our report confirms that KCNH1 mutations are associated with syndromic neurodevelopmental disorder, and also support the functional importance of the S4 domain.

  15. Epilepsy is a key phenotypic feature in most individuals with KCNH1-related syndromes, suggesting a direct role of KCNH1 in epileptogenesis, although the underlying mechanism is not understood.

  16. Findings show that the hEAG1 channel is directly regulated by PIP2 and that this regulation may contribute to normal human physiology and pathology.

  17. direct link between hERG 1b mutation and cardiomyocyte dysfunction

  18. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.

  19. Eag1 may serve as a potential indicator to predict tumor cell chemosensitivity. Silencing Eag1 may represent a potential therapeutic strategy to increase ovarian cancer sensitivity to cisplatin.

  20. The expression of Eag1 may be partially explained the aggressive behavior of triple negative breast cancer in the breast cancer tissue.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. n this report, we present two independent screening campaigns in which we wanted to identify small molecules that bind to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim (PAS) domain from the human EAG-related gene (ERG) channel or the amino or carboxy terminal globular domains from the mouse EAG1 channel, affecting their interaction.

  2. KV10.1 localizes to the centrosome and the primary cilium and promotes ciliary disassembly. Interference with KV10.1 ciliary localization abolishes not only the effects on ciliary disassembly, but also KV10.1-induced tumor progression in vivo Conversely.

  3. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.

  4. KV 10.1 opposes activity-dependent increase in calcium influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse

  5. deletion of Kv10.1 does not show a marked phenotype is a prerequisite for utilizing Kv10.1 blocking and/or reduction techniques, such as siRNA, to treat cancer.

  6. The flavonoids identified here potentiated EAG1 channels by binding to the CNBHD.

  7. 2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel

  8. Biochemical evidence was provided that suggests that there is also an unliganded conformation where the C-terminus of the domain peels away from its bound position. A role was shown for the cyclic nucleotide-homology domain in channel gating.

  9. X-ray diffraction of EAG channel data were collected to 2.2 A resolution and the crystal belonged to the hexagonal space group P3(1)21

  10. K(V)10.1 channels at the nuclear envelope might participate in the homeostasis of nuclear K(+), or indirectly interact with heterochromatin, both factors known to affect gene expression

  11. Single crystal of EAG PAS from Mus musculus belonging to space group P3221

  12. Ether-a-go-go-related gene K channels in interstitial cells of Cajal contribute to membrane potential and play role in regulation of pacemaker activity of small intestine.

  13. Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization

  14. Results indicate that cyclic nucleotides do not directly modulate mEAG1 and hERG1 channels.

  15. Both M-eag and its C. elegans homolog egl-2 are inhibited by the tricyclic antidepressant imipramine.

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) interaction partners

  1. These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) Antigen Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Gene names and symbols associated with KCNH1

  • potassium voltage-gated channel subfamily H member 1 (KCNH1) antibody
  • potassium channel, voltage gated eag related subfamily H, member 1 (KCNH1) antibody
  • potassium voltage-gated channel subfamily H member 1 (LOC490277) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1) antibody
  • potassium voltage-gated channel subfamily H member 1 (Kcnh1) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 1a (kcnh1a) antibody
  • bEAG antibody
  • EAG antibody
  • Eag1 antibody
  • h-eag antibody
  • kcnh1 antibody
  • Kv10.1 antibody
  • M-eag antibody

Protein level used designations for KCNH1

potassium voltage-gated channel, subfamily H (eag-related), member 1 , potassium voltage-gated channel, subfamily H, member 1 , potassium voltage-gated channel, subfamily H, member 1-like , potassium voltage-gated channel subfamily H member 1-like , ether-a-go-go potassium channel 1 , potassium voltage-gated channel subfamily H member 1 , voltage-gated potassium channel subunit Kv10.1 , EAG channel 1 , ether-a-go-go, Drosophila, homolog of , hEAG1 , EAG1 , ether a go-go , r-eag , potassium voltage-gated channel subfamily H member 1a

GENE ID SPECIES
421381 Gallus gallus
712190 Macaca mulatta
745653 Pan troglodytes
100022125 Monodelphis domestica
100051219 Equus caballus
100340515 Oryctolagus cuniculus
100457136 Pongo abelii
100475212 Ailuropoda melanoleuca
100541904 Meleagris gallopavo
100600409 Nomascus leucogenys
281881 Bos taurus
3756 Homo sapiens
490277 Canis lupus familiaris
16510 Mus musculus
65198 Rattus norvegicus
560568 Danio rerio
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