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vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa. Additionally we are shipping PROC Kits (42) and and many more products for this protein.
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Cow (Bovine) Polyclonal PROC Primary Antibody for EIA, RIA - ABIN613777
Satou, Nishi, Hishinuma, Hosoda, Kangawa, Sugimoto: Identification of activated protein C as a ghrelin endopeptidase in bovine plasma. in The Journal of endocrinology 2014
Data show that activated protein C signals via protease activated receptors PAR2 (show F2RL1 Antibodies)/PAR3 (show F2RL2 Antibodies) to expand Treg cells, mitigating the disease in mice.
insulin (show INS Antibodies) and aPC (show APC Antibodies) converge on a common spliced-X-box binding protein-1 (show XBP1 Antibodies) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.
APC (show APC Antibodies) modifies pulmonary fibrosis by limiting thrombin (show F2 Antibodies)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Antibodies)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Antibodies)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Antibodies) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (show PROCR Antibodies)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (show THBD Antibodies) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (show PLA2G2A Antibodies)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Antibodies) to promote protein C activation.
vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa
anticoagulant protein C
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, vitamin K-dependent protein C