Proteolipid Protein 1 Proteins (PLP1)

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. Additionally we are shipping Proteolipid Protein 1 Antibodies (48) and Proteolipid Protein 1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLP1 5354 P60201
Rat PLP1 PLP1 24943 P60203
PLP1 18823 P60202
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top Proteolipid Protein 1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human Un-conjugated „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
Synthetic Human Un-conjugated   50 μg Log in to see 3 to 4 Days

PLP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for Proteolipid Protein 1 (PLP1) Interaction Partners

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. Authors investigated the disease progression in mouse models carrying PLP1 point mutations previously found in patients displaying clinical features of multiple sclerosis. These mouse models show loss-of-function of PLP1 associated with neuroinflammation.

  2. Review focusing on sequences in hPLP1 intron 1 DNA deemed important for hPLP1 gene activity as well as a couple of "human-specific" supplementary exons within the first intron which are utilized to generate novel splice variants, and the potential role that these sequences may play in PLP1-linked disorders.

  3. it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of Multiple Sclerosis.

  4. Human induced pluripotent stem cells-derived oligodendrocytes from 12 individuals with Pelizaeus-Merzbacher and identified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor development, and oligodendrocyte morphology and capacity for myelination.

  5. report a novel mutation of the PLP1 gene in two siblings with Pelizaeus-Merzbacher disease associated with a rare and protean neuroimaging finding of optic nerve enlargement

  6. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  7. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  8. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  9. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  10. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP (show C3 Proteins) is replaced by the peripheral nerve myelin protein, P0.

  2. The observations collectively support the idea that GST-pi (show GSTP1 Proteins)(Nuc (show SREBF2 Proteins))/DM-20 mRNA-expressing cells are the progeny of NG2 (show Vcan Proteins)-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes.

  3. In the absence of P0, thus, PLP (show C3 Proteins) also contributes to myelination by Schwann cells and to the preservation of peripheral axons

  4. while PLP (show C3 Proteins) can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP (show C3 Proteins) cannot replace P0 as the major structural protein of PNS myelin.

  5. Both extracellular and intracellular epitopes of PLP (show C3 Proteins) contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  6. The insertion of native PLP (show C3 Proteins) into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  7. This study shows for the first time that Plp (show C3 Proteins)-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  8. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4 (show CD4 Proteins)+ T cell responses in a T cell-mediated autoimmune disease.

  9. that an early reactive glia response occurs following mutations in the PLP (show C3 Proteins) gene

  10. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth.

Proteolipid Protein 1 (PLP1) Protein Profile

Protein Summary

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with Proteolipid Protein 1 Proteins (PLP1)

  • proteolipid protein 1 (PLP1)
  • proteolipid protein 1 (Plp1)
  • proteolipid protein 1 (plp1)
  • proteolipid protein (myelin) 1 (Plp1)
  • myelin proteolipid protein (Tsp_11640)
  • myelin proteolipid protein (plp)
  • proteolipid protein 1 L homeolog (plp1.L)
  • proteolipid protein 1a (plp1a)
  • DKFZp459O081 protein
  • DKFZp459O113 protein
  • DM20 protein
  • DMalpha2c protein
  • GPM6C protein
  • hld1 protein
  • jimpy protein
  • jp protein
  • mmpl protein
  • msd protein
  • plp protein
  • PLP/DM20 protein
  • plp1 protein
  • plp1a protein
  • pmd protein
  • rsh protein
  • spg2 protein
  • wu:fc27f01 protein
  • wu:fj36d03 protein
  • wu:fj42d08 protein
  • zgc:110499 protein

Protein level used designations for Proteolipid Protein 1 Proteins (PLP1)

lipophilin , major myelin proteolipid protein , myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein, lipophilin , proteolipid protein 1 , myelin synthesis deficiency , rump shaker , PLP , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a , DMalpha1 , etID60288.14

5354 Homo sapiens
24943 Rattus norvegicus
281410 Bos taurus
397029 Sus scrofa
465785 Pan troglodytes
481002 Canis lupus familiaris
613099 Xenopus (Silurana) tropicalis
100009169 Oryctolagus cuniculus
100173486 Pongo abelii
100174736 Pongo abelii
18823 Mus musculus
396214 Gallus gallus
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
398334 Xenopus laevis
100220245 Taeniopygia guttata
64264 Danio rerio
100714212 Cavia porcellus
Selected quality suppliers for Proteolipid Protein 1 Proteins (PLP1)
Did you look for something else?