anti-RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) Antibodies

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].. Additionally we are shipping RAP1GDS1 Kits (6) and RAP1GDS1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAP1GDS1 310909  
RAP1GDS1 5910 P52306
RAP1GDS1 229877  
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Top anti-RAP1GDS1 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: RAP1GDS1  Sample Tissue: Human Fetal Heart  Antibody Dilution: 1.0 µg/mL Host: Rabbit  Target Name: RAP1GDS1  Sample Tissue: Human Fetal Brain  Antibody Dilution: 1.0 µg/mL 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed, paraffin embedded human brain tissue stained with RAP1GDS1 Antibody  followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of RAP1GDS1 Antibody  in HepG2,MDA-MB231 cell line lysates (35ug/lane). This demonstrates the RAP1GDS1 antibody detected the RAP1GDS1 protein (arrow 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded U373 xenograft, using RAP1GDS1, antibody at 1:500 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$537.17
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB RAP1GDS1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis in HepG2,MDA-MB231 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of RAP1GDS1 expression in transfected 293T cell line by RAP1GDS1 MaxPab polyclonal antibody.Lane 1: RAP1GDS1 transfected lysate(66.77 KDa).Lane 2: Non-transfected lysate. RAP1GDS1 MaxPab polyclonal antibody. Western Blot analysis of RAP1GDS1 expression in human liver. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL 16 Days
$814.00
Details

Top referenced anti-RAP1GDS1 Antibodies

  1. Human Polyclonal RAP1GDS1 Primary Antibody for ICC, IF - ABIN4349352 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against RAP1GDS1 Interaction Partners

Human RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) interaction partners

  1. SmgGDS-607 completely inhibits RhoA prenylation catalyzed by protein geranylgeranyltransferase I (GGTase-I) in an in vitro radiolabel incorporation assay. SmgGDS-607 inhibits prenylation by binding to and blocking access to the C-terminal tail of the small GTPase (substrate sequestration mechanism) rather than via inhibition of the prenyltransferase activity.

  2. Study reveals a cryptic pocket by which SmgGDS-558 accommodates RhoA prenylation, loosening the structure of Rho when it interacts with SmgGDS, which may enable drug development strategies for targeting SmgGDS and small GTPases.

  3. a novel nuclear role for SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression and tumorigenesis.

  4. Data suggest that SmgGDS-558 splice variant exhibits a fold containing tandem copies of armadillo-repeat motifs not present in other guanine nucleotide exchange factors (GEFs); SmgGDS harbors distinct positively and negatively charged regions, both of which play critical roles in binding to RhoA and in GEF activity. (SmgGDS = smg p21 stimulatory GDP exchange protein; RhoA = ras homolog gene family, member A)

  5. Unlike Rap1B, phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS-607.

  6. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF member.

  7. results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins

  8. DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS

  9. SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.

  10. TG2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1.

  11. findings identify SmgGDS-558 as an activator of RhoA and NF-kB in breast cancer, and demonstrate a functional role for SmgGDS-558 in the proliferation of breast cancer cells and tumorigenesis.

  12. this study provides evidence that SmgGDS-607 associates with GTPases through recognition of the last amino acid in the CAAX motif.

  13. These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.

  14. findings provide compelling evidence of a novel role for junctional adhesion molecule-A (JAM-A)in driving breast cancer cell migration via activation of Rap1 GTPase and beta1-integrin

  15. Results indicate that SmgGDS is a bona fide GEF that specifically activates RhoA and RhoC through a unique mechanism not used by other Rho family exchange factors.

  16. Results indicate that guanine nucleotide exchange and interactions with SmgGDS splice variants can regulate the entrance and passage of PBR-possessing small GTPases through the prenylation pathway.

  17. C3G stimulates guanine nucleotide exchange on Drosophila Rap GTPases in vitro

  18. ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma.

  19. activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes

  20. results demonstrate that B-CLL cells uniquely activate Rap1 in response to PDE4 inhibitors and suggest that physiologic stimuli that activate EPAC may transmit an antiapoptotic signal

Cow (Bovine) RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) interaction partners

  1. These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.

Mouse (Murine) RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) interaction partners

  1. Apoe(-/-) SmgGDS(+/-) mice showed significantly higher levels of oxidative stress, matrix metalloproteinases, and inflammatory cell migration in the ascending aorta compared with Apoe(-/-) mice. local delivery of the SmgGDS gene construct reversed the dilation of the ascending aorta in Apoe(-/-) SmgGDS(+/-) mice.

  2. Simulated microgravity activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis.

  3. results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins

  4. These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.

RAP1GDS1 Antigen Profile

Protein Summary

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993

Gene names and symbols associated with RAP1GDS1

  • Rap1 GTPase-GDP dissociation stimulator 1 (Rap1gds1) antibody
  • Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) antibody
  • RAP1, GTP-GDP dissociation stimulator 1 (Rap1gds1) antibody
  • RAP1, GTP-GDP dissociation stimulator 1 L homeolog (rap1gds1.L) antibody
  • BC011279 antibody
  • gds1 antibody
  • rap1gds1 antibody
  • smgGDS antibody
  • XsmgGDS antibody

Protein level used designations for RAP1GDS1

rap1 GTPase-GDP dissociation stimulator 1 , RAP1, GTP-GDP dissociation stimulator 1 , SMG GDS protein , SMG P21 stimulatory GDP/GTP exchange protein , exchange factor smgGDS , ralB-binding protein A , rap1 GTPase-GDP dissociation stimulator 1-A , smgGDS-A , xsmgGDS-A

GENE ID SPECIES
310909 Rattus norvegicus
100217715 Taeniopygia guttata
5910 Homo sapiens
282516 Bos taurus
229877 Mus musculus
394369 Xenopus laevis
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