SIN3 Transcription Regulator Homolog B (Yeast) Proteins (SIN3B)

Acts as a transcriptional repressor. Additionally we are shipping SIN3 Transcription Regulator Homolog B (Yeast) Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIN3B 23309 O75182
Rat SIN3B SIN3B 683381  
SIN3B 20467 Q62141
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Top SIN3 Transcription Regulator Homolog B (Yeast) Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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SIN3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SIN3 Transcription Regulator Homolog B (Yeast) (SIN3B) Interaction Partners

Zebrafish SIN3 Transcription Regulator Homolog B (Yeast) (SIN3B) interaction partners

  1. Sin3b is not essential in zebrafish

Human SIN3 Transcription Regulator Homolog B (Yeast) (SIN3B) interaction partners

  1. High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer.

  2. Low SIN3B expression is associated with Prostate Cancer Progression.

  3. these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes.

  4. The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners.

  5. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc.

  6. this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells.

  7. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression

  8. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes

  9. identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1

  10. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells

  11. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex

  12. The interaction between SIN3B and ETO required an intact amino-terminus of ETO and the NHR2 domain.

  13. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression.

  14. Modulation of Sin3B-associated activities may represent new therapeutic opportunities for treatment of cancers.

Mouse (Murine) SIN3 Transcription Regulator Homolog B (Yeast) (SIN3B) interaction partners

  1. this study shows that negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39

  2. Low SIN3B expression is associated with Prostate Cancer Progression.

  3. these results identify Sin3B as a novel and critical regulator of hematopoietic stem cells functions.

  4. adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.

  5. Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion.

  6. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression

  7. interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.

  8. Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population

  9. Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.

  10. RNF220 was identified as a novel ubiquitin ligase for Sin3B.

  11. ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression.

  12. When tethered in cis to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py) ori-dependent DNA replication in vivo.

  13. Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.

  14. The Myt1 family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B. Depending on the relative availability of Sin3B isoforms, the Myt1 gene family may favor the silencing of genes during neural development.

  15. Each of the four PAH domains of Sin3 seems to interact with a characteristic helix of a specific repressor; PAH1 needs a mostly hydrophobic helix and PAH2 needs an amphipathic helix in each target repressor.

  16. establish contrasting roles for the mSin3 proteins in the growth and development of specific lineages

  17. Sin3B plays an essential role in coordinating the chromatin modifying activities required for the transient repression of pro-proliferation genes in quiescence, as well as stable silencing of these genes upon terminal differentiation.

SIN3 Transcription Regulator Homolog B (Yeast) (SIN3B) Protein Profile

Protein Summary

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).

Gene names and symbols associated with SIN3B

  • SIN3 transcription regulator family member B (sin3b)
  • SIN3 transcription regulator family member B (SIN3B)
  • SIN3 transcription regulator family member B S homeolog (sin3b.S)
  • SIN3 transcription regulator family member B (Sin3b)
  • transcriptional regulator, SIN3B (yeast) (Sin3b)
  • 2810430C10Rik protein
  • fj63d08 protein
  • si:dkey-6n6.6 protein
  • wu:fj63d08 protein

Protein level used designations for SIN3B

paired amphipathic helix protein Sin3b , SIN3 homolog B, transcription regulator , SIN3 homolog B, transcriptional regulator , SIN3 transcription regulator homolog B , histone deacetylase complex subunit Sin3b , transcriptional corepressor Sin3b , transcriptional regulator, SIN3B , transcriptional regulator, SIN3 yeast homolog B

GENE ID SPECIES
560837 Danio rerio
23309 Homo sapiens
100036844 Xenopus laevis
520505 Bos taurus
683381 Rattus norvegicus
420140 Gallus gallus
610198 Canis lupus familiaris
20467 Mus musculus
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