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this study shows that negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39
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Low SIN3B expression is associated with Prostate Cancer Progression.
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these results identify Sin3B as a novel and critical regulator of hematopoietic stem cells functions.
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adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
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Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion.
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Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
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interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
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Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
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Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
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RNF220 was identified as a novel ubiquitin ligase for Sin3B.
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ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression.
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When tethered in cis to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py) ori-dependent DNA replication in vivo.
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Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.
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The Myt1 family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B. Depending on the relative availability of Sin3B isoforms, the Myt1 gene family may favor the silencing of genes during neural development.
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Each of the four PAH domains of Sin3 seems to interact with a characteristic helix of a specific repressor; PAH1 needs a mostly hydrophobic helix and PAH2 needs an amphipathic helix in each target repressor.
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establish contrasting roles for the mSin3 proteins in the growth and development of specific lineages
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Sin3B plays an essential role in coordinating the chromatin modifying activities required for the transient repression of pro-proliferation genes in quiescence, as well as stable silencing of these genes upon terminal differentiation.