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Acts as a transcriptional repressor. Additionally we are shipping SIN3 Transcription Regulator Homolog B (Yeast) Antibodies (54) and many more products for this protein.
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High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer.
Low SIN3B expression is associated with Prostate Cancer Progression.
these results suggest that stress-induced Sin3B activation is p53 (show TP53 Proteins)-dependent and is essential for p53 (show TP53 Proteins)-mediated repression of its selective target genes.
The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners.
A conserved Myc (show MYC Proteins) region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 (show HDAC1 Proteins) is recruited to Myc (show MYC Proteins)-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc (show MYC Proteins).
this study highlights an essential role for Sin3B in IFN-c induced COL1A2 (show COL1A2 Proteins) repression in smooth muscle cells.
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
the essential role of Sin3B as an important associate of p53 (show TP53 Proteins) in mediating the cellular responses to stress and in the transcriptional repression of genes
identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1 (show HDAC1 Proteins), Mrg15 (show MORF4L1 Proteins), and the PHD (show PDC Proteins) finger-containing Pf1
disruption of the function of a specific Sin3A (show SIN3A Proteins)/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells
these results identify Sin3B as a novel and critical regulator of hematopoietic stem cells functions.
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Proteins), Sp1 (show SP1 Proteins) and mSIN3B, which is a component of the SIN (show POLR3E Proteins) complex containing histone deacetylase (show HDAC1 Proteins), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Proteins) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 (show SP1 Proteins) and the mSIN3 complex.
Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 (show BMI1 Proteins) depletion.
interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
RNF220 was identified as a novel ubiquitin ligase for Sin3B.
ESET (show SETDB1 Proteins) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (show HDAC1 Proteins)/2 that participates in multiple pathways of transcriptional repression.
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).
paired amphipathic helix protein Sin3b
, SIN3 homolog B, transcription regulator
, SIN3 homolog B, transcriptional regulator
, SIN3 transcription regulator homolog B
, histone deacetylase complex subunit Sin3b
, transcriptional corepressor Sin3b
, transcriptional regulator, SIN3B
, transcriptional regulator, SIN3 yeast homolog B