anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) Antibodies

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Additionally we are shipping SMAD5 Proteins (14) and SMAD5 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMAD5 4090 Q99717
SMAD5 59328 Q9R1V3
SMAD5 17129 P97454
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Top anti-SMAD5 Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SMAD5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rat  Target Name:  SMAD5  Sample Tissue:  Rat Liver  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of SMAD5 expression in HeLa (A), mouse testis (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Figure 1: Western blot analysis using SMAD5 mouse mAb against Hela (1), SK-N-SH (2), PC-12 (3), Jurkat (4), and K562 (5) cell lysate. Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded brain tissues (left) and lung cancer tissues (right) using SMAD5 mouse mAb with DAB staining. Dilution: 1/200 - 1/1000 100 μL Log in to see 8 to 11 Days
$475.29
Details
Human Mouse Un-conjugated ELISA, FACS, IF, IHC, WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB Western blot analysis of extracts of various cell lines, using SMAD5 antibody. 100 μL Log in to see 16 Days
$334.77
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using SMAD5, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Log in to see 3 to 4 Days
$358.60
Details
Human Mouse Un-conjugated ELISA, IF, WB Immunofluorescence of monoclonal antibody to SMAD5 on HeLa cell (antibody concentration 10 µg/mL). SMAD5 monoclonal antibody (M01), clone 2D7. Western Blot analysis of SMAD5 expression in Jurkat. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human K562 Cells; Lane2: Human Hela Cells; Lane3: Human Jurkat Cells. 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Uterus, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
$493.17
Details

Top referenced anti-SMAD5 Antibodies

  1. Human Polyclonal SMAD5 Primary Antibody for WB - ABIN1881816 : Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. in Molecular bioSystems 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal SMAD5 Primary Antibody for ICC, FACS - ABIN969404 : Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SMAD5 Interaction Partners

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery.

  2. Differential expression of TGF-beta (show TGFB1 Antibodies) superfamily members and role of Smad1 (show GARS Antibodies)/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

  3. Data suggest that differences in expression levels in granulosa-like tumor cells and granulosa cells (GCs (show GCLC Antibodies)) from patients with polycystic ovary syndrome (PCOS) are due to increased expression of microRNA-27a-3p in GCs (show GCLC Antibodies) caused by insulin (show INS Antibodies) resistance in PCOS; microRNA-27a-3 expression is up-regulated in GCs (show GCLC Antibodies) in PCOS; overexpression of miR (show MLXIP Antibodies)-27a-3p inhibits SMAD5 expression and promotes apoptosis. (SMAD5 = SMAD family member 5)

  4. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD (show SMAD1 Antibodies) pathway may be a novel target in addressing cognitive deficit of SZ in future studies.

  5. the BMP-2 (show BMP2 Antibodies)/Smad1 (show GARS Antibodies)/5/RUNX2 (show RUNX2 Antibodies) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Antibodies) synth

  6. miR (show MLXIP Antibodies)-23a and miR (show MLXIP Antibodies)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (show FASL Antibodies)-Fas (show FAS Antibodies) pathway

  7. Our findings suggest that suppression of miR (show MLXIP Antibodies)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (show RUNX2 Antibodies) signaling axis.

  8. Overexpression of the BMP4 (show BMP4 Antibodies)/SMAD4 (show SMAD4 Antibodies)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  9. The polycomb group protein L3MBTL1 (show L3MBTL1 Antibodies) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  10. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (show AKT1 Antibodies) and SMAD1 (show GARS Antibodies)/5 during long-period culture.

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (show SMAD1 Antibodies)/5 and MAP kinase (show MAPK1 Antibodies) signaling system (ERK (show MAPK1 Antibodies) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (show SMAD1 Antibodies) and smad9 (show SMAD9 Antibodies) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (show FGF10 Antibodies), tgfb2 (show TGFB2 Antibodies), pax9 (show PAX9 Antibodies), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (show BMP4 Antibodies)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (show SMAD1 Antibodies) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. SMAD5 is crucial for expanding amniotic ectoderm rapidly into a stretchable squamous sheet to accommodate exocoelom expansion, axial growth and folding morphogenesis.

  2. CD137 (show TNFRSF9 Antibodies) signaling is a new regulator of angiogenesis by modulating the Smad1 (show SMAD1 Antibodies)/5-NFATc1 (show NFATC1 Antibodies) pathway.

  3. miR (show MLXIP Antibodies)-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. Inhibition of miR (show MLXIP Antibodies)-155 promoted osteogenic potential and thus it can be used as a potential target in the treatment of bone defects.

  4. Up-regulation of miR (show MLXIP Antibodies)-93 may contribute to the progression of morphine tolerance by targeting Smad5 in mouse model of bone cancer pain

  5. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Antibodies)) expression through S1PR2 (show S1PR2 Antibodies)/RhoA (show RHOA Antibodies)/ROCK/Smad1 (show SMAD1 Antibodies)/5/8 signaling.

  6. We discovered that Smad1 (show SMAD1 Antibodies)/5/4-Amhr2 (show AMHR2 Antibodies)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (show SMAD1 Antibodies)/5/4-Amhr2 (show AMHR2 Antibodies)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.

  7. these studies characterize an accessory TGF-beta (show TGFB1 Antibodies)-stimulated BMP R-Smad (show SMAD1 Antibodies) signaling mechanism in interstitial cells of the developing lung.

  8. Thyroid-specific Smad1 (show SMAD1 Antibodies) and Smad5 double-knockout (Smad1 (show SMAD1 Antibodies)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.

  9. Smad1 (show SMAD1 Antibodies) and Smad5 have overlapping functions to govern hepcidin (show HAMP Antibodies) transcription. Moreover, erythropoietin (show EPO Antibodies) and erythroferrone target Smad1 (show SMAD1 Antibodies)/5 signaling and require Smad1 (show SMAD1 Antibodies)/5 to suppress hepcidin (show HAMP Antibodies) expression.

  10. miR (show MLXIP Antibodies)-106b-5p and miR-17-5p are novel Smad5 regulators.

SMAD5 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5) antibody
  • SMAD family member 5 (Smad5) antibody
  • SMAD family member 5 (smad5) antibody
  • 1110051M15Rik antibody
  • AI451355 antibody
  • DKFZp468M0619 antibody
  • Dwf-C antibody
  • DWFC antibody
  • fb67b04 antibody
  • JV5-1 antibody
  • mad antibody
  • madh5 antibody
  • MusMLP antibody
  • sb:cb400 antibody
  • SBN antibody
  • SMAD5 antibody
  • smd5 antibody
  • wu:fb67b04 antibody

Protein level used designations for SMAD5

MAD, mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , SMAD 5 , mothers against DPP homolog 5 , SMAD family member 5 , pgy , piggytail , somitabun , Mothers against decapentaplegic homolog 5 , Smad 5 , dwarfin-C , mSmad5

GENE ID SPECIES
4090 Homo sapiens
59328 Rattus norvegicus
395679 Gallus gallus
30641 Danio rerio
481520 Canis lupus familiaris
768050 Bos taurus
100033851 Equus caballus
100173534 Pongo abelii
100303615 Sus scrofa
17129 Mus musculus
100717571 Cavia porcellus
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