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The protein encoded by SMARCD1 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Additionally we are shipping SMARCD1 Proteins (4) and and many more products for this protein.
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Mouse (Murine) Polyclonal SMARCD1 Primary Antibody for WB - ABIN1881818
Ho, Ronan, Wu, Staahl, Chen, Kuo, Lessard, Nesvizhskii, Ranish, Crabtree: An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 6 Pubmed References
Human Polyclonal SMARCD1 Primary Antibody for WB - ABIN1537324
Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. in Cancer research 2014
Human Polyclonal SMARCD1 Primary Antibody for ICC, IF - ABIN4354738
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
miR-223 targets the expression of SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinomas.
BAF57, BAF60a and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells
miR-7 expression reduced SMARCD1 protein expression in lung cancer cell lines.
the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with bone mineral density in white women, as conducted.
SMARCD1/BAF60a is an androgen receptor cofactor that modulates TMPRSS2 expression
In addition to previously identified BAF250, BAF60a may provide another critical and direct link between nuclear receptors and the BRG1 complex that is required for promoter recruitment and subsequent chromatin remodeling
work revealed functional redundancy between Baf60a and Baf60c in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance. Unexpectedly, mice lacking these two factors in skeletal muscle were protected from diet-induced and age-associated metabolic disorders. Transcriptional profiling analysis identified the muscle thermogenic gene program and myokine secretion as key pathways that inte
Hepatocyte-specific inactivation of Baf60a reduced bile acid production.
propose a role for SMARCD1 in restricting pluripotency and activating lineage pathways by regulating H3K27 methylation
hypermethylation-mediated silencing of miR-490-3p reactivates SMARCD1 to confer malignant phenotypes, mechanistically linking H. pylori, chromatin remodeling, and gastric carcinogenesis
Tbx1 expression increases Baf60a occupation of the Wnt5a gene and enhances its H3K4 monomethylation status, while Baf60a knockdown abolishes the ability of Tbx1 to regulate Wnt5a and other target genes.
Our data suggest a critical role for BAF60a in the coordinated regulation of hepatic circadian clock and energy metabolism in mammals.
These results suggest that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors by the interaction with p53.
PGC-1alpha mediates the recruitment of BAF60a to PPARalpha-binding sites, leading to transcriptional activation of peroxisomal and mitochondrial fat-oxidation genes.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1-like
, 60 kDa BRG-1/Brm-associated factor subunit A
, BRG1-associated factor 60A
, SWI/SNF complex 60 kDa subunit A
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
, Swp73-like protein
, chromatin remodeling complex BAF60A subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60A
, SWI/SNF complex 60 kDa subunit
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d1