Secretagogin, EF-Hand Calcium Binding Protein Proteins (SCGN)

Human Secretagogin, EF-Hand Calcium Binding Protein (SCGN) interaction partners

1. Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A (show STX1A Proteins) and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein (show PVALB Proteins) secretagogin, which dissociates from tomosyn1 in response to Ca(2 (show CA2 Proteins)+)-raising stimuli and is required for insulin (show INS Proteins) granule trafficking and exocytosis downstream of Ca(2 (show CA2 Proteins)+) influx.

2. secretagogin is a potential biomarker, reflecting stress and islet cell dysfunction in T2D patients

3. Secretagogin-dependent MMP2 (show MMP2 Proteins) release from neurons regulates neuroblast migration.

4. The low SCGN plasma levels in children with ASD (show ARSD Proteins) probably indicate that SCGN might be implicated in the pathogenesis of autism. However, these data should be treated with caution until further investigations are performed using larger sample sizes to determine whether the decrease in plasma SCGN levels is a mere consequence of autism or it plays a pathogenic role in the disease.

5. Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1 (show TRPV1 Proteins)-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of beta-cells.

6. These results suggest SCGN is involved in the chemoresistance of small cell lung cancer under the regulation of miR (show MLXIP Proteins)-494

7. Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn.

8. While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes.

9. Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease.

10. Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury.

Zebrafish Secretagogin, EF-Hand Calcium Binding Protein (SCGN) interaction partners

1. X-ray structure of Danio rerio secretagogin: A hexa (show HEXA Proteins)-EF-hand calcium sensor

Mouse (Murine) Secretagogin, EF-Hand Calcium Binding Protein (SCGN) interaction partners

1. Secretagogin-dependent MMP2 (show MMP2 Proteins) release from neurons regulates neuroblast migration.

2. Secretagogin affects insulin secretion in pancreatic beta-cells by regulating actin dynamics and focal adhesion

3. Scgn is a redox-responsive Ca(2 (show CA2 Proteins)+) sensor.

4. these data define a novel secretagogin neuronal locus and molecular axis underpinning stress responsiveness.

5. The Sirt1 (show SIRT1 Proteins)/DDAH2 (show DDAH2 Proteins)/secretagogin pathway is a novel regulator of glucose-stimulated insulin (show INS Proteins) secretion

6. Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn.

7. Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries.

8. scgn is a marker of neuroblasts commuting in the rostral migratory stream. Terminally differentiated neurons in the olfactory bulb retain scgn expression, with scgn being present in periglomerular cells and granular layer interneurons.