anti-Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) Antibodies

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. Additionally we are shipping SUCLA2 Proteins (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SUCLA2 20916 Q9Z2I9
SUCLA2 8803 Q9P2R7
SUCLA2    
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SUCLA2 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , B: Molt-4 , 10% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using SUCLA2, antibody at 1:200 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts from 293, using SUCLA2 antibody. Lane 1 was treated with the blocking peptide. Western blot analysis of extracts of PC-3 cells, using SUCLA2 antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using SUCLA2 antibody. Western blot analysis of extracts of various cell lines, using SUCLA2 antibody (ABIN4905339) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s. 100 μL 11 to 13 Days
$366.77
Details
Chicken Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IHC, IHC (p), WB   100 μL 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical staining of human stomach with SUCLA2 polyclonal antibody  shows cytoplasmic positivity in glandular cells. Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with SUCLA2 polyclonal antibody . 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated IF/ICC, IHC (fp), WB   100 μL 6 to 8 Days
$431.20
Details

More Antibodies against SUCLA2 Interaction Partners

Mouse (Murine) Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) interaction partners

  1. SCS A-beta loss mediates severe mitochondrial dysfunction including compromised OXPHOS efficiency, increased ROS generation, mtDNA depletion as well as altered mitochondrial dynamics towards fusion.

  2. Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion.

  3. ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity

Human Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) interaction partners

  1. SUCLA2 mutation is associated with Down syndrome and mitochondrial depletion syndrome.

  2. The patient's cells lack the SUCLG1 protein, with significantly reduced levels of SUCLA2 and SUCLG2 protein

  3. Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells.

  4. Long survival, to age 20 years or older, was reported in 12% of SUCLA2 and in 10% of SUCLG1 patients.

  5. XDH and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.

  6. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism

  7. SUCLA2 mutations should be analyzed in patients with slowly progressive encephalomyopathy, even in the absence of methylmalonic aciduria or mitochondrial DNA depletion.

  8. This study demonstrated that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex.

  9. Identification of a novel mutation in SUCLA2 in two cousins affected with encephalomyopathy, is reported.

  10. A novel homozygous mutation in SUCLA2 gene has been associated with severe mitochondrial encephalomyopathies in two Italian siblings.

  11. 3 novel mutations have been identified in patients with the mitochondrial DNA depletion syndrome (c.1048G>A and c.1049G>T in SUCLA2 and c.531+4A>T in SUCLG1).

  12. X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 mutations that cause loss of binding to the beta-subunit of succinyl-CoA synthetase (SUCLA2).

  13. Mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria is associated with mutations in SUCLA2, the gene encoding a beta subunit of succinate-CoA ligase.

  14. Deficiency of SUCLA2 is associated with encephalomyopathy and mitochondrial DNA depletion.

SUCLA2 Antigen Profile

Protein Summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.

Gene names and symbols associated with SUCLA2

  • succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2) antibody
  • succinate-CoA ligase ADP-forming beta subunit (SUCLA2) antibody
  • 4930547K18Rik antibody
  • A-BETA antibody
  • MTDPS5 antibody
  • SCS antibody
  • SCS-betaA antibody

Protein level used designations for SUCLA2

ATP-specific succinyl-CoA synthetase subunit beta , SCS-betaA , succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial , succinyl-CoA synthetase beta-A chain , ATP-specific succinyl-CoA synthetase, beta subunit , mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta , renal carcinoma antigen NY-REN-39 , ATP-specific succinyl-CoA synthetase beta , Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial

GENE ID SPECIES
20916 Mus musculus
8803 Homo sapiens
511090 Bos taurus
485448 Canis lupus familiaris
399540 Sus scrofa
Selected quality suppliers for anti-SUCLA2 (SUCLA2) Antibodies
Did you look for something else?