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SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Additionally we are shipping Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Antibodies (97) and many more products for this protein.
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Our data show that the differential expression of SUV39H1 and SUV39H2 (show SUV39H2 Proteins) is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution
Overexpression of miR (show MLXIP Proteins)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.
KAT7 (show MYST2 Proteins)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.
Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (show CBX5 Proteins) and gamma, and enhances HP1beta (show CBX1 Proteins) levels.
we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1
These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (show DEFA1 Proteins)/DNMT3A (show DNMT3A Proteins) in DNA methylation (show HELLS Proteins)-based epigenetic silencing
PHF2 (show PHF1 Proteins) is likely to repress rDNA transcription by competing with PHF8 (show PHF8 Proteins) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
High SUV39H1 expression is associated with hepatocellular carcinoma.
Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (show BCL2 Proteins), pro-caspase-9 (show CASP9 Proteins), pro-caspase-3 (show CASP3 Proteins) and C-myc (show MYC Proteins). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.
Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin (show FN1 Proteins) and p21(WAF1 (show CDKN1A Proteins)) in mesangial cells
Activation of p38alpha (show MAPK14 Proteins) displaces KMT1A from MyoD (show MYOD1 Proteins) to initiate myogenic gene expression upon induction of myoblasts differentiation.
Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (show CBX5 Proteins) to the promoter of the ancestral Oct4 (show POU5F1 Proteins) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.
Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.
Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
These findings indicate that Suv39h1 enhances AP-2alpha (show TFAP2A Proteins)-mediated transcriptional repression of C/EBPalpha (show CEBPA Proteins) in an epigenetic manner and further inhibits adipocyte differentiation.
A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.
Data indicate that loss of suv39h1 prevents Myc (show MYC Proteins)-induced chromosomal instability.
Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (show IL2 Proteins) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (show IL2 Proteins) transcription.
The identification of a histone H3 (show HIST3H3 Proteins) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
These results suggest that Dnmt1 (show DNMT1 Proteins) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (show DNMT1 Proteins) and Suv39h1 help guide the terminal differentiation of particular tissues.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
histone-lysine N-methyltransferase SUV39H1
, su(var)3-9 homolog 1
, Su(var)3-9 homolog 1
, histone H3-K9 methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 1
, lysine N-methyltransferase 1A
, position-effect variegation 3-9 homolog
, H3-K9-HMTase 1
, Suv39h histone methyltransferase
, histone-lysine N-methyltransferase SUV39H1-A
, su(var)3-9 homolog 1-A
, suppressor of variegation 3-9 homolog 1
, suppressor of variegation 3-9 homolog 1-A
, suppressor of variegation 3-9-like 1a