Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteins (SUV39H1)

SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Additionally we are shipping Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Antibodies (101) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUV39H1 6839 O43463
SUV39H1 20937 O54864
Rat SUV39H1 SUV39H1 302553  
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Top Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,144.17
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Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$3,144.17
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,173.50
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Escherichia coli (E. coli) Human GST tag SUV39H1 activity assay. Recombinant SUV39H1 activity measured using a fluorescent histone H3 lysine 9 methyltransferase assay. SUV39H1 protein gel. SUV39H1 (4.2 μg) run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SUV39H1. 25 μg Log in to see 1 to 2 Days
$472.50
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SUV39H1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaction Partners

Human Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. Here, the authors demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H1 with constitutive heterochromatin in human cells.

  2. Here the authors show that Suv39h1 chromodomain binds nucleic acids, and this binding is important for its function in heterochromatin assembly.

  3. SirT6 (show SIRT6 Proteins) promotes cysteine ubiquitination in the PRE-SET domain of Suv39h1.

  4. Our data show that the differential expression of SUV39H1 and SUV39H2 (show SUV39H2 Proteins) is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution

  5. Overexpression of miR (show MLXIP Proteins)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.

  6. KAT7 (show MYST2 Proteins)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.

  7. Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (show CBX5 Proteins) and gamma, and enhances HP1beta (show CBX1 Proteins) levels.

  8. we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1

  9. These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.

  10. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (show DEFA1 Proteins)/DNMT3A (show DNMT3A Proteins) in DNA methylation (show HELLS Proteins)-based epigenetic silencing

Mouse (Murine) Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. The authors show here that the mouse Suv39h2 (show SUV39H2 Proteins) enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA.

  2. Suv39h1 plays a critical role in marking chromatin to silence stem/memory genes during CD8 (show CD8A Proteins)+ T effector terminal differentiation

  3. Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin (show FN1 Proteins) and p21(WAF1 (show CDKN1A Proteins)) in mesangial cells

  4. Overexpression of miR (show MLXIP Proteins)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.

  5. Activation of p38alpha (show MAPK14 Proteins) displaces KMT1A from MyoD (show MYOD1 Proteins) to initiate myogenic gene expression upon induction of myoblasts differentiation.

  6. Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (show CBX5 Proteins) to the promoter of the ancestral Oct4 (show POU5F1 Proteins) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.

  7. Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.

  8. Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.

  9. These findings indicate that Suv39h1 enhances AP-2alpha (show TFAP2A Proteins)-mediated transcriptional repression of C/EBPalpha (show CEBPA Proteins) in an epigenetic manner and further inhibits adipocyte differentiation.

  10. A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.

Zebrafish Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) interaction partners

  1. The identification of a histone H3 (show HIST3H3 Proteins) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.

  2. These results suggest that Dnmt1 (show DNMT1 Proteins) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (show DNMT1 Proteins) and Suv39h1 help guide the terminal differentiation of particular tissues.

Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Protein Profile

Protein Summary

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

Gene names and symbols associated with SUV39H1

  • suppressor of variegation 3-9 homolog 1 L homeolog (suv39h1.L)
  • suppressor of variegation 3-9 homolog 1 (SUV39H1)
  • suppressor of variegation 3-9 homolog 1 (Drosophila) (Suv39h1)
  • suppressor of variegation 3-9 homolog 1a (suv39h1a)
  • AI852103 protein
  • AL022883 protein
  • DXHXS7466e protein
  • fe02c04 protein
  • H3-K9-HMTase 1 protein
  • KMT1A protein
  • MG44 protein
  • mIS6 protein
  • RGD1565028 protein
  • SUV39H protein
  • suv39h1 protein
  • wu:fe02c04 protein
  • zgc:101027 protein

Protein level used designations for SUV39H1

histone-lysine N-methyltransferase SUV39H1 , su(var)3-9 homolog 1 , Su(var)3-9 homolog 1 , histone H3-K9 methyltransferase 1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 1 , lysine N-methyltransferase 1A , position-effect variegation 3-9 homolog , H3-K9-HMTase 1 , Suv39h histone methyltransferase , histone-lysine N-methyltransferase SUV39H1-A , su(var)3-9 homolog 1-A , suppressor of variegation 3-9 homolog 1 , suppressor of variegation 3-9 homolog 1-A , suppressor of variegation 3-9-like 1a

GENE ID SPECIES
431943 Xenopus laevis
6839 Homo sapiens
491868 Canis lupus familiaris
523047 Bos taurus
20937 Mus musculus
302553 Rattus norvegicus
100172621 Pongo abelii
445198 Danio rerio
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