Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2A Kits (19) and Ubiquitin-Conjugating Enzyme E2A Proteins (15) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal ube2a Primary Antibody for ICC, IF - ABIN151985
Dul, Walworth: The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity. in The Journal of biological chemistry 2007
Show all 2 Pubmed References
RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients.
RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor.
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.
This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.
RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
RAD6A is a regulator of Parkin-dependent mitophagy plays a critical role in maintaining neuronal function.
UBE2A specifically interacts with CDK9, but not CDK2 and is phosphorylated by CDK9 in vitro.
RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53.
UBE2A deficiency syndrome is reported in two male patients.
showed that the function of FA signaling pathway is at least partly mediated through coupling with hRad6/hRad18 signaling (HHR6 pathway)
Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome
high resolution backbone structure from nmr
A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease.
results indicate a causal role of UBE2A in learning and mGLUR-dependent long-term depression
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.
signaling through Notch modulates the turnover of E2A proteins
absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2 A
, ubiquitin-conjugating enzyme E2A (RAD6 homolog)
, ubiquitin-conjugating enzyme E2A
, RAD6 homolog A
, ubiquitin carrier protein A
, ubiquitin-protein ligase A
, ubiquitin-conjugating enzyme E2A, RAD6 homolog
, ubiquitin-conjugating enzyme HR6A