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Zmpste24 encodes a member of the peptidase M48A family. Additionally we are shipping Zinc Metalloproteinase, Ste24 Proteins (7) and Zinc Metalloproteinase, Ste24 Kits (2) and many more products for this protein.
Showing 10 out of 126 products:
Human Polyclonal Zmpste24 Primary Antibody for ICC, IF - ABIN250782
Corrigan, Kuszczak, Rusinol, Thewke, Hrycyna, Michaelis, Sinensky: Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. in The Biochemical journal 2005
Show all 4 Pubmed References
Human Polyclonal Zmpste24 Primary Antibody for WB - ABIN1882012
Fontaine-Bisson, Alessi, Saut, Fumeron, Marre, Dutour, Badens, Levy, Tichet, Juhan-Vague, Trégouët, Balkau, Morange: Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. in Journal of molecular medicine (Berlin, Germany) 2010
Show all 3 Pubmed References
Polyclonal Zmpste24 Primary Antibody for WB - ABIN540233
Young, Fong, Michaelis: Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. in Journal of lipid research 2005
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Human Polyclonal Zmpste24 Primary Antibody for IHC (p), WB - ABIN389048
Kumagai, Kawamura, Yanagisawa, Komano: Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p. in Biochimica et biophysica acta 1999
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Human Polyclonal Zmpste24 Primary Antibody for ELISA, WB - ABIN251680
Fong, Frost, Meta, Qiao, Yang, Coffinier, Young: A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. in Science (New York, N.Y.) 2006
Human Polyclonal Zmpste24 Primary Antibody for IHC (p), WB - ABIN389049
Moulson, Go, Gardner, van der Wal, Smitt, van Hagen, Miner: Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. in The Journal of investigative dermatology 2005
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ZMPSTE24 is a downstream effector of IFITM3 (show IFITM3 Antibodies) and is important for interferon (show IFNA Antibodies)-induced transmembrane antiviral activity.
ZMPSTE24 is an important element for innate host defense against a broad spectrum of pathogenic viruses.
This case demonstrates that accumulation of prelamin A, independent of the loss of function of ZMPSTE24 metallopeptidase (show ECEL1 Antibodies) that catalyzes processing of prelamin A, can cause a progeroid disorder and that a cell biology assay could be used in precision medicine to identify a potential therapy.
used a fluorogenic assay of the activity of purified ZMPSTE24 to demonstrate that HIV protease inhibitors directly inhibit the human enzyme in a manner indicative of a competitive mechanism
the present study suggests that inhibition of ZMPSTE24 by both mutational and expressional pathways might together play a role in tumorigenesis of colorectal cancer and gastric cancer harboring microsatellite instability phenotype.
results establish that the substrate profile of Ste24p is broader than anticipated, being more similar to that of the M16A protease family than that of the Rce1p CAAX protease with which it has been functionally associated
ZMPSTE24 downregulation is a major contributor in VSMC dysfunctions resulting from LMNA (show LMNA Antibodies) mutations or PI treatments that could translate in early atherosclerosis at the clinical level.
Here, we report on a familial c.50delA (p.Lys17Serfs*21) mutation of the ZMPSTE24 gene, causing RD in two siblings.
complete loss-of-function of ZMPSTE24 leads to RD, whereas other less severe phenotypes are associated with at least one haploinsufficient allele.
miR (show MLXIP Antibodies)-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.
we identified the abnormal lamin A (show LMNA Antibodies) (prelamin A), accompanied by a down-regulation of a lamin A (show LMNA Antibodies) processing enzyme (Zmpste24) in the kidney of the GMF (show GMFB Antibodies) transgenic mice
In Zmpste24(-/-) mice, histone H4 (show HIST1H4H Antibodies) was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase (show HAT Antibodies), Mof (show KAT8 Antibodies), to the nuclear matrix.
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype
the progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna (show LMNA Antibodies)
Lack of functional Zmpste24, a metalloproteinase responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice
Zmpste24 deficiency elicits a stress signalling pathway that is evidenced by a marked upregulation of p53 (show TP53 Antibodies) target genes, and accompanied by a senescence phenotype at the cellular level and accelerated ageing at the organismal level
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
, zinc metallopeptidase (STE24 homolog)
, zinc metallopeptidase STE24 homolog
, zinc metalloproteinase STE24 homolog
, CAAX prenyl protease 1 homolog
, STE24 endopeptidase
, zinc metalloproteinase
, zinc metallopeptidase STE24
, CAAX prenyl protease 1 homolog-like
, farnesylated proteins-converting enzyme 1
, prenyl protein-specific endoprotease 1
, zinc metalloproteinase Ste24 homolog
, zinc metallopeptidase, STE24 homolog
, zinc metalloproteinase, STE24 homolog
, farnesylated-proteins converting enzyme 1
, zinc metalloproteinase (STE24 homolog, yeast)