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AGE Products

(Advanced Glycation End Products (AGE))
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008].

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Featured AGE Categories

AGE Antibodies

High quality antibodies with extensive validation data.

AGE ELISA Kits

Reliable ELISA kits for a wide range of species.

AGE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended AGE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (3)
  • (2)
Cat. No. ABIN738516
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Human
Application
Validations
Cat. No. ABIN3027441
Quantity 1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (fro), IHC (p), WB
Validations
Cat. No. ABIN738518
Quantity 100 μL
Datasheet Datasheet

Recommended AGE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Various Species
Analytical Method Quantitative Competition ELISA
Validations
  • (23)
  • (1)
Cat. No. ABIN6953551
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
  • (1)
Cat. No. ABIN6973597
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964670
Quantity 96 tests
Datasheet Datasheet

Recommended AGE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity General
Source
Validations
Cat. No. ABIN1877203
Quantity 50 μg
Datasheet Datasheet
Reactivity All Species
Source Human
Validations
Cat. No. ABIN6239805
Quantity 50 μg
Datasheet Datasheet
Reactivity General
Source Human
Validations
Cat. No. ABIN6119733
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our AGE products

Liu, Shen, Chen, Cao, Di, Lan, Chen, Bai, Han, Xu: "Inhibition of RAGE by FPS-ZM1 alleviates renal injury in spontaneously hypertensive rats." in: European journal of pharmacology, pp. 173228, (2020) (PubMed).

Chou, Wu, Yang, Shen, Yang: "Effect of Advanced Glycation End Products on the Progression of Alzheimer's Disease." in: Journal of Alzheimer's disease : JAD, Vol. 72, Issue 1, pp. 191-197, (2020) (PubMed).

Han, Ma, Zhu, Sun, Liu: "Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway." in: Molecular and cellular endocrinology, Vol. 514, pp. 110878, (2020) (PubMed).

Pawlukianiec, Gryciuk, Mil, Żendzian-Piotrowska, Zalewska, Maciejczyk: "A New Insight into Meloxicam: Assessment of Antioxidant and Anti-Glycating Activity in In Vitro Studies." in: Pharmaceuticals (Basel, Switzerland), Vol. 13, Issue 9, (2020) (PubMed).

Tang, Yu, Wu, Chen, Zeng, Wang, Yang, Mei, Cao, Qin: "Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 251-263, (2018) (PubMed).

Wang, Chen, Du, Long, Reed, Hu, Suppiramaniam, Hong, Tang: "Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice." in: Neuropharmacology, Vol. 131, pp. 143-153, (2018) (PubMed).

Chen, Chen, Wu, Chou, Chen, Wei, Lee, Hong, Zheng, Chiu, Lin, Hsu, Hsu: "Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice." in: Scientific reports, Vol. 7, pp. 40442, (2017) (PubMed).

Yang, Meng, Chen, Li, Cen, Wen, Zhang, Li: "Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 41, Issue 2, pp. 742-754, (2017) (PubMed).

Galiniak, Bartosz, Sadowska-Bartosz: "Glutathione is the main endogenous inhibitor of protein glycation." in: General physiology and biophysics, Vol. 36, Issue 2, pp. 175-186, (2017) (PubMed).

Qiu, Tang, Wei: "Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy." in: Molecular and cellular endocrinology, Vol. 443, pp. 89-105, (2017) (PubMed).

Synonyms and alternative names related to AGE

renin binding protein (RENBP), RBP, RNBP

Protein level used designations for AGE

  • AGE
  • GlcNAc 2-epimerase
  • N-acetyl-D-glucosamine 2-epimerase
  • N-acylglucosamine 2-epimerase
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