Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human SREBF1 Antibodies:
anti-Mouse (Murine) SREBF1 Antibodies:
anti-Rat (Rattus) SREBF1 Antibodies:
Go to our pre-filtered search.
Chicken Monoclonal SREBF1 Primary Antibody for SimWes, WB - ABIN153469
Yin, Zhang, Hillgartner: Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. in The Journal of biological chemistry 2002
Show all 24 Pubmed References
Cow (Bovine) Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN151638
Johnston-Cox, Koupenova, Yang, Corkey, Gokce, Farb, LeBrasseur, Ravid: The A2b adenosine receptor modulates glucose homeostasis and obesity. in PLoS ONE 2012
Show all 10 Pubmed References
Hamster Monoclonal SREBF1 Primary Antibody for IP, WB - ABIN967563
Sakai, Nohturfft, Cheng, Ho, Brown, Goldstein: Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. in The Journal of biological chemistry 1997
Show all 4 Pubmed References
Human Monoclonal SREBF1 Primary Antibody for EMSA, IP - ABIN2668814
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. in PLoS ONE 2014
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN4355909
Johnson, McDowell, Viereck, Xia: Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. in Toxicological sciences : an official journal of the Society of Toxicology 2011
Human Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN4355907
Dahlhoff, Worsch, Sailer, Hummel, Fiamoncini, Uebel, Obeid, Scherling, Geisel, Bader, Daniel: Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. in Molecular metabolism 2014
CpG sites located in SREBF2 (show SREBF2 Antibodies) gene showed differential methylation in association with lipid traits. The expression of SREBF1 gene was inversely associated with methylation of its corresponding CpGs. Genetic variants in SREBF1 were also associated with lipid profile. SREBF1 expression was directly associated with HDL (show HSD11B1 Antibodies) cholesterol.
Epidermal growth factor receptor (EGFR (show EGFR Antibodies)) signaling enhances miR (show MLXIP Antibodies)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein
Intracranial GBM xenografts were used to determine the effects of genetically silencing SOAT1 (show SOAT1 Antibodies) and SREBP-1 on tumor growth.
Our finding reveals a crucial roles for SREBP1 in lipid desaturation of ccRCC through regulation of NF-kappaB (show NFKB1 Antibodies) signaling, which provides not only new insights in regulatory mode of NF-kappaB (show NFKB1 Antibodies) signaling but also a novel target for potential metabolic therapies.
Our results suggest that relatively common genetic variants in stearoyl CoA desaturase (show SCD Antibodies) and SREBF1 attenuated the positive associations between intake of a traditional diet rich in n-3 polyunsaturated fatty acids and increases in fasting cholesterol and HbA1c levels, as well as the waist-to-hip ratio among Yup'ik participants.
changes in distinct lipid ratios may converge on ARF1 (show ARF1 Antibodies) to increase SBP-1 (show MEGF8 Antibodies)/SREBP-1 activity.
Variants in the TOM1L2/SREBF1 (show TOM1L2 Antibodies) locus exert opposing effects of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD (show BEST1 Antibodies)) .
Date indicate that sterol regulatory element-binding proteins Srebp1 and Srebp2 (show SREBF2 Antibodies) are essential for the metabolic reprogramming of NK cells and for the attainment of elevated glycolysis and oxidative phosphorylation.
Study identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibit (show FAS Antibodies)ed expression of SREBP-1c and (show ACACA Antibodies)fatty acid synthase (FAS) and then repressed oleic acid-induced hepatic cell triglyceride (TG) and lipid droplet (LD) accumulation.
Glucose adsorption to chitosan membranes increases proliferation of human chondrocytes via mammalian target of rapamycin (show FRAP1 Antibodies) complex 1 and sterol regulatory element-binding protein-1 signaling.
Results showed that Glrx (show GRX1 Antibodies)(-/-) mice exhibited decreased SirT1 (show SIRT1 Antibodies) activity that leads to hyperacetylation and activation of SREBP-1 and upregulation of key hepatic enzymes involved in lipid synthesis.
Inhibition of NAMPT (show NAMPT Antibodies) aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1 (show SIRT1 Antibodies)/AMPKalpha (show GRK4 Antibodies)/SREBP1 signaling pathway.
SREBP1 is dramatically reduced in dysbindin-1 (show DTNBP1 Antibodies) knockout mice; possibly related to cognitive deficits.
Epidermal growth factor receptor (EGFR (show EGFR Antibodies)) signaling enhances miR (show MLXIP Antibodies)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1
The expression of hHL promoted hepatic triglyceride accumulation and de novo lipogenesis without affecting triglyceride secretion, and this was associated with an upregulation of Srebf1 (show TOM1L2 Antibodies) as well as the main genes controlling the synthesis of fatty acids. Transgenic mice also exhibited more adiposity and an increased LPL (show LPL Antibodies)-mediated FFA influx into the WAT without affecting glucose tolerance
Data show that miR (show MLXIP Antibodies)-200b and miR (show MLXIP Antibodies)-200c could directly bind the 3' UTR (show UTS2R Antibodies) of JUN (show JUN Antibodies), and JUN (show JUN Antibodies) activated the transcription of srebp1 to increase lipid accumulation.
a novel role for SREBP-1 as a cell surface retention factor for TbetaRI (show TGFBR1 Antibodies) in mesangial cells, is reported.
Srebp1c is a key regulator of metabolic remodeling leading to the beneficial effects of caloric restriction.
The present study indicates a requirement for C/EBPbeta (show CEBPB Antibodies) in the insulin (show INS Antibodies)-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha (show NR1H3 Antibodies), our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 (show SREBF2 Antibodies) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (show NR1H3 Antibodies) activity and SREBP-1c expression.
In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS (show FAS Antibodies), Acetyl-CoA carboxylase alpha (show ACACA Antibodies) (ACCalpha), and less hepatic and plasma TG after being fed a high-fat diet.
dysregulation of SIRT1 (show SIRT1 Antibodies)-AMPK (show PRKAA1 Antibodies)-SREBP and stimulation of NLRP3 (show NLRP3 Antibodies) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
Polymorphisms of the ACACA (show ACACA Antibodies) and SREBF1 genes are promising markers for pig carcass and performance traits.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
Basal transcription and supra-additive stimulation of porcine LDLR (show LDLR Antibodies) gene transcription by LH and insulin (show INS Antibodies) in granulosa-luteal cells require SREBP-1a and Sp1 (show SP1 Antibodies)/Sp3 (show SP3 Antibodies)-binding elements.
Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF (show MDFI Antibodies)) and back fat thickness (BF).
SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs.
SREBP1a activated while C/EBP (show CEBPA Antibodies) factors downregulated the activity of the SCD1 (show SCD Antibodies) promoter.
These results suggest that increased expression of hepatic CD36 (show CD36 Antibodies) and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB (show NFKB1 Antibodies) inflammatory pathway were both overinduced in cows with fatty liver.
SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.
data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes
84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.
genetic polymorphisms in sterol regulatory element binding transcription factor 1 (SREBF1)can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition
The results of this study demonstrated the existence of the polymorphisms in the SCD1 (show SCD Antibodies) and SREBP-1 genes in the population of Fleckvieh cattle and their associations with the concentrations of several muscle fat and subscutaneous fat fatty acids.
These results provide detailed genetic information for the SREBP1 signalling pathway and SCD (show SCD Antibodies) that can be used to change milk fat composition by marker-assisted breeding.
The SREBP1-9 SNP showed a significant effect on marbling score, monounsaturated fatty acids and C18 (show BBS9 Antibodies):1n-9 in the muscle fat of commercial Korean cattle.
the ability of Pu-erh (show ERH Antibodies) tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD (show SCD Antibodies), thereby reducing fat storage.
SBP-1/SREBP-1 is part of a conserved feedback loop responding to phosphatidylcholine (show SGMS1 Antibodies) levels to regulate expression of one-carbon cycle biogenesis genes and ensure adequate S-adenosylmethionine levels for phosphatidylcholine (show SGMS1 Antibodies) production.
elo-5 and elo-6 may be transcriptional targets of LPD (show ACSBG1 Antibodies)-1
both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid
Essential role of sbp-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, class D basic helix-loop-helix protein 1
, sterol regulatory element-binding protein 1
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element binding protein 1
, adipocyte determination and differentiation-dependent factor 1
, sterol regulatory binding transcription factor 1
, sterol regulatory element-binding transcription factor 1
, sterol regulatory element binding-protein 1
, sterol regulatory element binding transcription factor 1
, sterol response element binding protein 1
, similar to sterol regulatory element binding transcription factor 1 isoform b
, sterol regulatory element binding protein-1
, sterol regulatory element-binding protein 1-like
, Sterol regulatory element Binding Protein family member (sbp-1)
, Sterol regulatory element-binding transcription factor 1