Prostaglandin D2 Receptor 2 (PTGDR2) antibody
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- Target See all Prostaglandin D2 Receptor 2 (PTGDR2) Antibodies
- Prostaglandin D2 Receptor 2 (PTGDR2)
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2.
- Isotype
- IgG
- Top Product
- Discover our top product PTGDR2 Primary Antibody
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- Application Notes
- PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μg/mL.
- Comment
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(IN) Prostaglandin D2 receptor 2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C
- Storage Comment
- PTGDR2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
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- Target
- Prostaglandin D2 Receptor 2 (PTGDR2)
- Alternative Name
- PTGDR2 (PTGDR2 Products)
- Synonyms
- CD294 antibody, CRTH2 antibody, DL1R antibody, DP2 antibody, GPR44 antibody, Crth2 antibody, Grp45 antibody, Ptgdr2 antibody, Gpr44 antibody, prostaglandin D2 receptor 2 antibody, PTGDR2 antibody, Ptgdr2 antibody
- Background
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The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
Synonyms: Prostaglandin D2 receptor 2, chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTH2, G protein-coupled receptor 44, GPR44, CD294, DL1R, DP2 - Molecular Weight
- 43 kDa (calculated)
- Gene ID
- 11251
- NCBI Accession
- NP_004769
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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