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CEACAM1/5 antibody

CEACAM1/5 Reactivity: Human WB, FACS, ELISA, cELISA, IHC (fro) Host: Mouse Monoclonal 4-3-17 unconjugated
Catalog No. ABIN108735
  • Target See all CEACAM1/5 products
    CEACAM1/5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/5 (CEACAM1/5))
    Reactivity
    Human
    Host
    • 7
    • 5
    Mouse
    Clonality
    • 10
    • 2
    Monoclonal
    Conjugate
    • 11
    • 1
    This CEACAM1/5 antibody is un-conjugated
    Application
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Cell-ELISA (cELISA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Anti-human CEACAM1, 5 (BGP, CEA, CD66a,e)
    Purification
    Protein G
    Immunogen
    immunisation with extracted protein of CEACAM5
    Clone
    4-3-17
    Isotype
    IgG1
  • Application Notes
    Flow cytometry: 1.2 µg/10^6 cells
    ELISA: 1:200 - 1:400
    CELISA: 1:200 Western blot: 4 µg/mL
    Immunohistology: 1-2 µg/10^6 cells (on cryosections)
    For each application a titration should be performed to determine the optimal concentration.
    Comment

    Synonyms: CD66ae, BGP, CEA

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS, pH 7.2
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C
    Storage Comment
    short term: 2 °C - 8 °C, long term: -20 °C
  • Target
    CEACAM1/5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/5 (CEACAM1/5))
    Alternative Name
    CEACAM1,5 (CEACAM1/5 Products)
    Synonyms
    CD66e antibody, CEA antibody, carcinoembryonic antigen related cell adhesion molecule 5 antibody, CEACAM5 antibody
    Background
    Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
    UniProt
    P06731, P13688
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