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SNCA antibody (AA 1-140)
SNCA
Reactivity: Human
WB
Host: Mouse
Monoclonal
4H11
unconjugated
Product Details anti-SNCA Antibody
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Target
See all SNCA Antibodies
SNCA
(Synuclein, alpha (SNCA))
Binding Specificity
All epitopes for SNCA antibodies
AA 1-140
Reactivity
All reactivities for SNCA antibodies
Human
Host
All hosts for SNCA antibodies
Mouse
Clonality
All clonalities for SNCA antibodies
Monoclonal
Conjugate
All conjugates for SNCA antibodies
This SNCA antibody is un-conjugated
Application
All applications for SNCA antibodies
Western Blotting (WB)
Specificity
This antibody recognizes the recombinant α-synuclein
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein G affinity purified
Immunogen
Recombinant human alpha-synuclein (1-140 aa) expressed in E. coli
Clone
4H11
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
0.01 M PBS pH 7.2
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store at -20 °C.
Target Details for SNCA
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Target
SNCA
(Synuclein, alpha (SNCA))
Alternative Name
alpha-Synuclein / SNCA (SNCA Products )
Synonyms
snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
Background
Alpha-Synuclein belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. Alpha-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble Aβ into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and is also observed in senile plaques of Alzheimer's disease patients. Human α-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Gene ID
6622
NCBI Accession
NP_000336
UniProt
P37840
Pathways
Synaptic Membrane , Regulation of G-Protein Coupled Receptor Protein Signaling , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process , Platelet-derived growth Factor Receptor Signaling , Negative Regulation of Transporter Activity , Regulation of long-term Neuronal Synaptic Plasticity
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