This antibody is expected to recognize all reported isoforms of APP (NP_000475.1, NP_958816.1, NP_958817.1, NP_001129601.1, NP_001129602.1) and to recognize all lengths of the Amyloid beta peptide.
Cross-Reactivity (Details)
Species reactivity (expected):Canine (Dog), Bovine, Porcine. Species reactivity (tested):Human, Mouse.
Purification
Affinity Chromatography
Immunogen
Peptide with sequence DAEFRHDSGYEVHHQK-C, from the N-Terminus of the protein sequence according to NP_000475.1, NP_958816.1, NP_958817.1, NP_001129601.1, NP_001129602.1. Genename: APP
Amyloid Precursor Protein (APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II