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Transferrin Receptor antibody
TFRC
Reactivity: Human
WB, IP, IHC (fro), EIA
Host: Mouse
Monoclonal
3B8 2A1
unconjugated
Product Details anti-Transferrin Receptor Antibody
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Target
See all Transferrin Receptor (TFRC) Antibodies
Transferrin Receptor (TFRC)
(Transferrin Receptor (p90, CD71) (TFRC))
Reactivity
All reactivities for Transferrin Receptor antibodies
Human
Host
All hosts for Transferrin Receptor antibodies
Mouse
Clonality
All clonalities for Transferrin Receptor antibodies
Monoclonal
Conjugate
All conjugates for Transferrin Receptor antibodies
This Transferrin Receptor antibody is un-conjugated
Application
All applications for Transferrin Receptor antibodies
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
Specificity
This antibody detects Transferrin receptor 1.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein G
Clone
3B8 2A1
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.1 mg/mL
Buffer
PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store at 2 - 8 °C.
Target Details for Transferrin Receptor
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Target
Transferrin Receptor (TFRC)
(Transferrin Receptor (p90, CD71) (TFRC))
Alternative Name
CD71 / TFRC (TFRC Products )
Synonyms
Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody
Background
Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45 % identity with TfR2.Synonyms: TfR1, Transferrin receptor protein 1, p90
Gene ID
7037
NCBI Accession
NP_001121620
UniProt
P02786
Pathways
Transition Metal Ion Homeostasis
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