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FLIP antibody (C-Term, long form)
CFLAR
Reactivity: Human, Mouse, Rat
WB, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FLIP Antibody
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Target
See all FLIP (CFLAR) Antibodies
FLIP (CFLAR)
(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
Binding Specificity
All epitopes for FLIP antibodies
C-Term, long form
Reactivity
All reactivities for FLIP antibodies
Human, Mouse, Rat
Host
All hosts for FLIP antibodies
Rabbit
Clonality
All clonalities for FLIP antibodies
Polyclonal
Conjugate
All conjugates for FLIP antibodies
This FLIP antibody is un-conjugated
Application
All applications for FLIP antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
Recognizes FLIP-L No cross reactivity with other proteins.
Purification
Immunoaffinity Chromatography
Immunogen
A synthetic peptide corresponding to a sequence mapping at the C-terminal of Human FLIP- L, identical to the related Mouse sequence.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore with 0.2 mL of distilled water to yield a concentration of 0.5 mg/mL.
Concentration
0.5 mg/mL
Buffer
5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg Sodium Azide
Preservative
Sodium azide, Thimerosal (Merthiolate)
Precaution of Use
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody after reconstitution at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for FLIP
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Target
FLIP (CFLAR)
(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
Alternative Name
CFLAR / Casper / I-FLICE (CFLAR Products )
Synonyms
Clarp1 antibody, cflar antibody, CFLAR antibody, FLIP antibody, CASH antibody, CASP8AP1 antibody, CLARP antibody, Casper antibody, FLAME antibody, FLAME-1 antibody, FLAME1 antibody, I-FLICE antibody, MRIT antibody, c-FLIP antibody, c-FLIPL antibody, c-FLIPR antibody, c-FLIPS antibody, 2310024N18Rik antibody, A430105C05Rik antibody, Cash antibody, ENSMUSG00000072980 antibody, Flip antibody, Gm9845 antibody, c-Flip antibody, CASP8 and FADD-like apoptosis regulator a antibody, CASP8 and FADD like apoptosis regulator antibody, CASP8 and FADD like apoptosis regulator S homeolog antibody, CASP8 and FADD-like apoptosis regulator antibody, cflara antibody, CFLAR antibody, cflar antibody, cflar.S antibody, Cflar antibody
Background
Irmler et al. (1997) isolated human cDNAs encoding 2 isoforms of FLIP. FLIP(L), the longer isoform, contains 2 DEDs and a caspase-like domain, and FLIP(S), the shorter isoform, contains only the 2 DEDs followed by a C-terminal extension of approximately 50 amino acids. High levels of FLIP(L) protein were detected in melanoma cell lines and malignant melanoma tumors. FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP
Gene ID
8837
NCBI Accession
NP_001120655
UniProt
O15519
Pathways
Apoptosis , Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development
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