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SMAD1 antibody (C-Term)
SMAD1
Reactivity: Human, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SMAD1 Antibody
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Target
See all SMAD1 Antibodies
SMAD1
(SMAD, Mothers Against DPP Homolog 1 (SMAD1))
Binding Specificity
All epitopes for SMAD1 antibodies
AA 442-456, C-Term
Reactivity
All reactivities for SMAD1 antibodies
Human, Rat
Host
All hosts for SMAD1 antibodies
Rabbit
Clonality
All clonalities for SMAD1 antibodies
Polyclonal
Conjugate
All conjugates for SMAD1 antibodies
This SMAD1 antibody is un-conjugated
Application
All applications for SMAD1 antibodies
Western Blotting (WB)
Specificity
This antibody detects SMAD1/2/3/5 (C-term, 442-456). No cross reactivity with other proteins.
Cross-Reactivity (Details)
Species reactivity (tested):Human, rat
Purification
Immunogen affinity purified
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5 (442-456aa), identical to the related rat sequence
Isotype
IgG
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Discover our top product SMAD1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer
5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
Preservative
Sodium azide, Thimerosal (Merthiolate)
Precaution of Use
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target Details for SMAD1
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Target
SMAD1
(SMAD, Mothers Against DPP Homolog 1 (SMAD1))
Alternative Name
SMAD1 (SMAD1 Products )
Synonyms
MLP antibody, Xmad1 antibody, Xsmad1 antibody, bsp1 antibody, jv4-1 antibody, jv41 antibody, madh1 antibody, madr1 antibody, smad-1 antibody, MADH1 antibody, fb39h09 antibody, wu:fb39h09 antibody, wu:fb97e04 antibody, 2/23 antibody, CG12399 antibody, Dmel\\CG12399 antibody, E(zen)2 antibody, En(vvl) antibody, MAD antibody, Mat antibody, P-Mad antibody, P-mad antibody, PMad antibody, Smad antibody, Smad1 antibody, apg antibody, c28 antibody, dMAD antibody, dMad antibody, l(2)K00237 antibody, l(2)k00237 antibody, mad antibody, p-Mad antibody, pMAD antibody, pMad antibody, pSmad antibody, BSP-1 antibody, BSP1 antibody, JV4-1 antibody, JV41 antibody, MADR1 antibody, AI528653 antibody, Madh1 antibody, Madr1 antibody, Mlp1 antibody, MusMLP antibody, smad1 antibody, xmad antibody, SMAD family member 1 antibody, Mothers against dpp antibody, SMAD family member 1 L homeolog antibody, smad1 antibody, SMAD1 antibody, Mad antibody, Smad1 antibody, smad1.L antibody
Background
SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs,often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.Synonyms: 2, 3, 5, SMAD1, SMAD2, SMAD3, SMAD5
Gene ID
4086
NCBI Accession
NP_001003688
UniProt
Q15797
Pathways
Stem Cell Maintenance , Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development
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