Synaptophysin antibody
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- Target See all Synaptophysin (SYP) Antibodies
- Synaptophysin (SYP)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This Synaptophysin antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Anti-Synaptophysin reacts with neuroendocrine cells of Human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth's cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human.
- Purification
- Purified
- Clone
- MRQ-40
- Isotype
- IgG
- Top Product
- Discover our top product SYP Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, 0.09 % Sodium Azide, 0.9 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Synaptophysin (SYP)
- Alternative Name
- Synaptophysin / SYP (SYP Products)
- Synonyms
- syp-B antibody, xsypii antibody, MGC86267 antibody, MRXSYP antibody, A230093K24Rik antibody, AI848995 antibody, Syn antibody, p38 antibody, Syp1 antibody, mrxsyp antibody, syp antibody, xsypi antibody, synaptophysin S homeolog antibody, synaptophysin antibody, synaptophysin L homeolog antibody, synaptophysin a antibody, syp.S antibody, SYP antibody, syp antibody, Syp antibody, syp.L antibody, sypa antibody
- Background
- Synaptophysin is a synaptic vesicle glycoprotein with 4 transmembrane domain MW 38 kDa. Thisproteinis present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is also marker of endocrine tumors. It is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker
- Gene ID
- 6855
- NCBI Accession
- NP_003170
- UniProt
- P08247
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
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