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Vinculin antibody
VCL
Reactivity: Human
WB, IHC (fro), EIA
Host: Mouse
Monoclonal
FB11
unconjugated
Product Details anti-Vinculin Antibody
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Target
See all Vinculin (VCL) Antibodies
Vinculin (VCL)
Reactivity
All reactivities for Vinculin antibodies
Human
Host
All hosts for Vinculin antibodies
Mouse
Clonality
All clonalities for Vinculin antibodies
Monoclonal
Conjugate
All conjugates for Vinculin antibodies
This Vinculin antibody is un-conjugated
Application
All applications for Vinculin antibodies
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
Specificity
The antibody reacts with the Vinculin antigen. In Immunoblotting the antibody identifies a 130 kDa polypeptide.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Purified
Immunogen
Purified Vinculin from Human smooth muscle. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Clone
FB11
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.1 mg/mL
Buffer
PBS, 0.09 % Sodium Azdie, 1 % BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C.
Target Details for Vinculin
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Target
Vinculin (VCL)
Abstract
VCL Products
Synonyms
CMD1W antibody, CMH15 antibody, MV antibody, MVCL antibody, VCL antibody, im:6902790 antibody, hm:zehn2160 antibody, DDBDRAFT_0186762 antibody, DDBDRAFT_0232320 antibody, DDB_0186762 antibody, DDB_0232320 antibody, 9430097D22 antibody, AA571387 antibody, AI462105 antibody, AW545629 antibody, CG3299 antibody, CT11081 antibody, Dmel\\CG3299 antibody, Dmvincp antibody, EG:103B4.1 antibody, Vin antibody, Vin2EF antibody, vinc antibody, LOC100228062 antibody, vcl-A antibody, vinculin antibody, vinculin a antibody, vinculin A antibody, Vinculin antibody, vinculin S homeolog antibody, VCL antibody, vcla antibody, vinA antibody, Vcl antibody, Vinc antibody, CpipJ_CPIJ013873 antibody, Bm1_37935 antibody, vcl antibody, vcl.S antibody
Background
Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and alpha actinin, which in turn binds to actin. The binding of fibronectin is also indirect where vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor which itself is the ligand for fibronectin. Vinculin is widely distributed in tissue and is expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix.Synonyms: Metavinculin
Gene ID
7414
NCBI Accession
NP_003364
UniProt
P18206
Pathways
Cell-Cell Junction Organization , Maintenance of Protein Location , Signaling Events mediated by VEGFR1 and VEGFR2
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