PIDD antibody (P53-Induced Death Domain Protein) (AA 776-910)

Details for Product anti-PIDD Antibody No. ABIN1169268, Supplier: Log in to see
Antigen
  • 1200011D09Rik
  • AU042446
  • Pidd
  • LRDD
  • Lrdd
  • p53 induced death domain protein 1
  • p53-induced death domain protein 1
  • Pidd1
  • PIDD1
Alternatives
anti-Human PIDD antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 776-910
4
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
46
37
28
2
1
1
1
1
Host
Rabbit
47
6
Clonality
Polyclonal
Conjugate
This PIDD antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
36
19
13
10
5
5
4
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Recombinant human PIDD (Death Domain: aa 776-910).
Specificity Recognizes human and the native form of mouse PIDD. Detects bands of ~90 kDa (full length protein) and ~50 kDa (cleaved protein) by Western blot.
Cross-Reactivity Human, Mouse (Murine)
Plasmids, Primers & others Plasmids, Primers & others PIDD products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PIDD (PIDD Antibody Abstract)
Background PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
UniProt Q9HB75
Pathways p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date 12 months
Product cited in: Milleron, Bratton: "Heat shock induces apoptosis independently of any known initiator caspase-activating complex." in: The Journal of biological chemistry, Vol. 281, Issue 25, pp. 16991-7000, 2006 (PubMed).

Janssens, Tinel, Lippens, Tschopp: "PIDD mediates NF-kappaB activation in response to DNA damage." in: Cell, Vol. 123, Issue 6, pp. 1079-92, 2005 (PubMed).

Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, 2004 (PubMed).

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