PIDD antibody

Catalog No. ABIN7261141

Product Details anti-PIDD Antibody

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIDD antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human PIDD (NP_665893.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000 IHC 1:50-1:200 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Alternative Name: PIDD (PIDD Products)

Synonyms: 1200011D09Rik antibody, AU042446 antibody, Pidd antibody, LRDD antibody, Lrdd antibody, p53 induced death domain protein 1 antibody, p53-induced death domain protein 1 antibody, Pidd1 antibody, PIDD1 antibody

Background: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 100-110 kDa

Calculated_MW: 33 kDa/37 kDa/58 kDa/66 kDa/82 kDa/97 kDa/99 kDa

Gene ID: 55367

UniProt: Q9HB75

Pathways: p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity