PIDD antibody (AA 1-85)

Catalog No. ABIN1680710

The Rabbit Polyclonal anti-PIDD antibody is suitable to detect PIDD in samples from Human. It has been validated for IHC, WB and IF.

Quick Overview for PIDD antibody (AA 1-85) (ABIN1680710)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIDD antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PIDD Antibody

Binding Specificity: AA 1-85

Sequence: MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ LLQVEFLRLS THEDPQLLEA TLAQL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human PIDD (NP_665893.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Alternative Name: PIDD

Background: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.,PIDD1,LRDD,PIDD,Cancer,Tumor suppressors,p53 pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,PIDD

Molecular Weight: 33 kDa/37 kDa/58 kDa/66 kDa/82 kDa/97 kDa/99 kDa

Gene ID: 55367

UniProt: Q9HB75

Pathways: p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity