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ITGA2 antibody

ITGA2 Reactivity: Human, Monkey FACS Host: Mouse Monoclonal AK7 unconjugated
Catalog No. ABIN118699
  • Target See all ITGA2 Antibodies
    ITGA2 (Integrin alpha 2 (ITGA2))
    Reactivity
    • 127
    • 56
    • 21
    • 12
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Monkey
    Host
    • 82
    • 44
    • 19
    • 5
    • 3
    Mouse
    Clonality
    • 81
    • 75
    Monoclonal
    Conjugate
    • 63
    • 23
    • 17
    • 14
    • 9
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA2 antibody is un-conjugated
    Application
    • 66
    • 64
    • 42
    • 38
    • 14
    • 14
    • 13
    • 12
    • 10
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Specificity
    This antibody recognises the integrin alpha2 subunit, which is a 160 kDa glycoprotein that non-covalently associates with the 130 kDa integrin beta1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, endothelial cells, monocytes and most adherent cell lines. Cross reacts with Cynomolgus monkey (3), Baboon and Rhesus monkey.
    Purification
    Affinity chromatography on Protein G
    Immunogen
    Spleen cells from immunised mice were fused with cells of the mouse NS1 myeloma cell line.
    Clone
    AK7
    Isotype
    IgG1
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  • Application Notes
    Flow cytometry: 1/50 - 1/100, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunohistochemistry on frozen sections: 1/500 - 1/1000. Recommended positive control tissue: Tonsil.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ITGA2 (Integrin alpha 2 (ITGA2))
    Alternative Name
    CD49b / ITGA2 (ITGA2 Products)
    Synonyms
    BR antibody, CD49B antibody, GPIa antibody, HPA-5 antibody, VLA-2 antibody, VLAA2 antibody, DX5 antibody, integrin subunit alpha 2 antibody, integrin alpha 2 antibody, ITGA2 antibody, Itga2 antibody
    Background
    CD49b is a 160kD glycoprotein that non-covalently associates with the 130kD integrin beta 1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, approximately 50 % of monocytes and most adherent cell lines. MCA743 inhibits cell attachment to collagen.Synonyms: CD49 antigen-like family member B, Collagen Receptor, GPIa, ITGA-2, Integrin alpha-2, Platelet membrane glycoprotein Ia, VLA-2 alpha, VLA2
    Gene ID
    3673
    NCBI Accession
    NP_002194
    UniProt
    P17301
    Pathways
    CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex
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