CD80 antibody

Catalog No. ABIN134038

Product Details anti-CD80 Antibody

Target: CD80

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD80 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Mouse CD80 (B7-1)

Purification: Purified

Isotype: IgG2a

Application Details

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/ml

Buffer: Purified Ig buffered in PBS, 0.1% NaN and EIA grade BSA to bring total protein concentration to 4-5 mg/ml.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD80

Target: CD80

Alternative Name: CD80 (CD80 Products)

Synonyms: B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody

Background: ABIN134038reacts with the murine CD80 (B7-1) molecule. This member of the Ig superfamily, along with CD86 (B7-2), participates in T cell co- stimulation via interactions with CD28 and CTLA-4. CD80 is constitutively ex- pressed on dendritic cells, monocytes, and peritoneal macrophages and it is in- ducible on B cells by various means, including activation by LPS, IL-4, and the cross-linking of surface Ig. Expression of CD80 is greatly enhanced on splenic B cells following activation by LPS, with peak expression occurring between 48 and 72 hours. It has been reported that activation of purified B cells with LPS can induce CD80 expression in as few as 18 hours.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints