SORL1 antibody (AA 2001-2100)

Catalog No. ABIN1387514

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Binding Specificity: AA 2001-2100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SorLA

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SorLA (SORL1 Products)

Synonyms: SORL1 antibody, C11orf32 antibody, LR11 antibody, LRP9 antibody, SORLA antibody, SorLA-1 antibody, gp250 antibody, SorLA antibody, 2900010L19Rik antibody, AI596264 antibody, AW261561 antibody, mSorLA antibody, Lr11 antibody, RGD619914 antibody, sortilin related receptor 1 antibody, sortilin-related receptor antibody, sortilin-related receptor, L(DLR class) A repeats containing antibody, sortilin-related receptor, L(DLR class) A repeats-containing antibody, sortilin-related receptor, LDLR class A repeats-containing antibody, sorl1 antibody, LOC582560 antibody, SORL1 antibody, Sorl1 antibody

Background:

Synonyms: C11orf32, FLJ21930, FLJ39258, gp250, LDLR relative with 11 ligand binding repeats, LDLR relative with 11 ligand-binding repeats, Low density lipoprotein receptor relative with 11 ligand binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LR 11, LR11, LRP 9, LRP9, Mosaic protein LR11, SORL 1, SORL_HUMAN, SORL1, SorLA 1, SorLA, SorLA-1, Sortilin related receptor, Sortilin related receptor LDLR class A repeats containing, Sortilin-related receptor, Sorting protein related receptor containing LDLR class A repeats, Sorting protein-related receptor containing LDLR class A repeats,

Background: Sortilin-related receptor, also known as Sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL (the main cholesterol-carrying lipoprotein of plasma) and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP, receptor-associated protein. SorLa is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous sorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. It is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Gene ID: 79845

Pathways: Smooth Muscle Cell Migration