ATRIP antibody (pSer68, pSer72) (Alexa Fluor 350)
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- Target See all ATRIP Antibodies
- ATRIP (ATR Interacting Protein (ATRIP))
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Binding Specificity
- pSer68, pSer72
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ATRIP antibody is conjugated to Alexa Fluor 350
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human ATRIP around the phosphorylation site of Ser68 + Ser72 [LA(p-S)QAL(p-S)QC]
- Isotype
- IgG
- Top Product
- Discover our top product ATRIP Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- ATRIP (ATR Interacting Protein (ATRIP))
- Alternative Name
- ATRIP+ (ATRIP Products)
- Synonyms
- 6620401K05Rik antibody, TREX1 antibody, Xatrip antibody, trex1 antibody, si:dkey-42i9.5 antibody, ATRIP antibody, CG7347 antibody, Dmel\\CG7347 antibody, Mus304 antibody, anon-WO0140519.82 antibody, atrip antibody, mus(3)304 antibody, mus-304 antibody, ATR interacting protein antibody, ATR interacting protein S homeolog antibody, mutagen-sensitive 304 antibody, ATRIP, ATR checkpoint kinase regulatory subunit Rad26 antibody, ATRIP antibody, Atrip antibody, atrip.S antibody, atrip antibody, mus304 antibody, rad26 antibody
- Background
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Synonyms: ATRIP phospho S68 + S72, ATRIP Ser68 + Ser72, P-ATRIP Ser68/Ser72, AGS 1, AGS1, AGS-1, Aicardi Goutieres syndrome 1, ATIP, ATM and Rad3 related interacting protein, ATM and Rad3-related-interacting protein, ATR interacting protein, ATR-interacting protein, Atrip, ATRIP_HUMAN, Deoxyribonuclease III dnaQ/mutD E. coli like, DKFZp434J0310, DKFZp762J2115, DNase III, DRN 3, DRN3, FLJ12343, MGC20625, MGC26740, Three prime repair exonuclease 1, TREX 1, TREX1, TREX1 protein, MGC21482, 3' repair exonuclease 1, 3'-5' exonuclease TREX1.
Background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.
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