HFE2 antibody (AA 205-255) (Cy7)
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- Target See all HFE2 Antibodies
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
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Binding Specificity
- AA 205-255
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HFE2 antibody is conjugated to Cy7
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule C
- Isotype
- IgG
- Top Product
- Discover our top product HFE2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
- Alternative Name
- RGMC/Repulsive Guidance Molecule C (HFE2 Products)
- Synonyms
- HFE2A antibody, HJV antibody, JH antibody, RGMC antibody, HFE2 antibody, DKFZp468F2322 antibody, 2310035L15Rik antibody, 5230400G09Rik antibody, AI414844 antibody, AI789733 antibody, DL-M antibody, Rgmc antibody, hemojuvelin antibody, RGMr antibody, hjv antibody, id:ibd3464 antibody, wu:fb38f10 antibody, zgc:136698 antibody, hemochromatosis type 2 (juvenile) antibody, hemochromatosis type 2 antibody, HFE2 antibody, Hfe2 antibody, hfe2 antibody
- Background
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Synonyms: DL M, Haemojuvelin, HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, Hemochromatosis type 2 juvenile, Hemochromatosis type 2, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, HEMOCHROMATOSIS, TYPE 2A, HEMOCHROMATOSIS, TYPE 2B, Hemojuvelin, HFE 2, Hfe2, HFE2A, HJV, JH, Juvenile, MGC23953, Repulsive guidance molecule c, RGM C, RGM domain family member C, RGMC, RGMC_HUMAN.
Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).
- Pathways
- Transition Metal Ion Homeostasis
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