BPTF antibody (AA 2801-3046) (HRP)

Catalog No. ABIN1410368

Product Details anti-BPTF Antibody (HRP)

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Binding Specificity: AA 2801-3046

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BPTF antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BPTF/FALZ

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BPTF

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Alternative Name: BPTF/FALZ (BPTF Products)

Synonyms: FAC1 antibody, FALZ antibody, NURF301 antibody, 9430093H17Rik antibody, Falz antibody, BPTF antibody, bromodomain PHD finger transcription factor antibody, nucleosome-remodeling factor subunit NURF301 antibody, fetal alzheimer antigen, falz antibody, BPTF antibody, Bptf antibody, LOC5576547 antibody, CpipJ_CPIJ011285 antibody, bptf antibody

Background:

Synonyms: Bromodomain and PHD finger containing transcription factor, Bromodomain PHD finger transcription factor, FAC 1, BPTF / FALZ, fac1, FALZ, Fetal Alz 50 clone 1 protein, Fetal Alz 50 reactive clone 1, Fetal Alzheimer antigen, Nucleosome remodeling factor, Nucleosome remodeling factor subunit BPTF, Nucleosome remodeling factor, large subunit, NURF 301, NURF301.

Background: BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyze ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.