Kv1.4 antibody (AA 555-653) (Cy5.5)

Catalog No. ABIN1413533

The Rabbit Polyclonal anti-Kv1.4 antibody is suitable to detect Kv1.4 in samples from Human. It has been validated for IF (cc) and IF (p).

Quick Overview for Kv1.4 antibody (AA 555-653) (Cy5.5) (ABIN1413533)

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kv1.4 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Kv1.4 Antibody (Cy5.5)

Binding Specificity: AA 555-653

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kv1.4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Kv1.4

Target: Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))

Alternative Name: Kv1.4

Background:

Synonyms: Voltage gated K+ channel HuKII, cardiac potassium channel, fetal skeletal muscle potassium channel, HBK 4, HBK4, HK 1, HK1, HPCN 2, HPCN2, HUK II, HUKII, KCNA 4, KCNA 8, KCNA4, KCNA4_HUMAN, KCNA4L, KCNA8, kv1.4, PCN 2, PCN2, potassium channel 2, potassium channel KCNA4, potassium channel protein, Potassium voltage gated channel shaker related subfamily member 4, Potassium voltage gated channel subfamily A member 4, potassium voltage-gated channel shaker-related subfamily member 4-like, Potassium voltage-gated channel subfamily A member 4, rapidly inactivating potassium channel, Shaker related potassium channel Kv1.4, shaker-related potassium channel Kv1.4, type A potassium channel, Voltage gated potassium channel HBK4, Voltage gated potassium channel HK1, Voltage gated potassium channel subunit Kv1.4, Voltage-gated K+ channel HuKII, voltage-gated potassium channel, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, voltage-gated potassium channel protein Kv1.4, Voltage-gated potassium channel subunit Kv1.4.

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.