MLF1 antibody (HRP)

Catalog No. ABIN1419166

Product Details anti-MLF1 Antibody (HRP)

Target: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLF1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MLF1/2/3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MLF1

Target: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Alternative Name: MLF1 (MLF1 Products)

Synonyms: MLF1 antibody, HLS7 antibody, myeloid leukemia factor 1 antibody, myeloid leukemia factor 1 L homeolog antibody, MLF1 antibody, mlf1.L antibody, mlf1 antibody, Mlf1 antibody

Background:

Synonyms: Hls7, MLF1, MLF2, MLF3, MLF1_HUMAN, Myelodysplasia myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, Myeloid leukemia factor 1, myeloid leukemia factor 1 variant 1, myeloid leukemia factor 1 variant 2, myeloid leukemia factor 1 variant 3.

Background: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene ID: 4291